AMY1A

Amylase, alpha 1A; salivary
PDB rendering based on 1b2y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b2y​, 1bsi​, 1c8q​, 1cpu​, 1hny​, 1jxj​, 1jxk​, 1kb3​, 1kbb​, 1kbk​, 1kgu​, 1kgw​, 1kgx​, 1mfu​, 1mfv​, 1nm9​, 1q4n​, 1smd​, 1u2y​, 1u30​, 1u33​, 1xcw​, 1xcx​, 1xd0​, 1xd1​, 1xgz​, 1xh0​, 1xh1​, 1xh2​, 1xv8​, 1z32​, 2cpu​, 3cpu​
Identifiers
Symbols	AMY1A ; AMY1; AMY1B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86951
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amylase, alpha 1A; salivary, also known as AMY1A, is a human gene. This gene is found in many organisms, see Alpha-Amylase.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.

Further reading

• Bank RA, Hettema EH, Arwert F; et al. (1991). "Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase". Electrophoresis. 12 (1): 74–9. doi:10.1002/elps.1150120114. PMID 1710976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot PC, Mager WH, Henriquez NV; et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. PMID 2081604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishide T, Nakamura Y, Emi M; et al. (1986). "Primary structure of human salivary alpha-amylase gene". Gene. 41 (2–3): 299–304. PMID 2423416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davis MM, Hodes ME, Munsick RA; et al. (1986). "Pancreatic amylase expression in human pancreatic development". Hybridoma. 5 (2): 137–45. PMID 2424823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Handy DE, Larsen SH, Karn RC, Hodes ME (1987). "Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1". Mol. Biol. Med. 4 (3): 145–55. PMID 2442579.CS1 maint: Multiple names: authors list (link)
• Horii A, Emi M, Tomita N; et al. (1988). "Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene". Gene. 60 (1): 57–64. PMID 2450054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gumucio DL, Wiebauer K, Caldwell RM; et al. (1988). "Concerted evolution of human amylase genes". Mol. Cell. Biol. 8 (3): 1197–205. PMID 2452973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Res. 16 (17): 8261–76. PMID 2458567.CS1 maint: Multiple names: authors list (link)
• Groot PC, Bleeker MJ, Pronk JC; et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. PMID 2788608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pronk JC, Frants RR, Jansen W; et al. (1982). "Evidence of duplication of the human salivary amylase gene". Hum. Genet. 60 (1): 32–5. PMID 6176528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zabel BU, Naylor SL, Sakaguchi AY; et al. (1984). "High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization". Proc. Natl. Acad. Sci. U.S.A. 80 (22): 6932–6. PMID 6196780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somat. Cell Mol. Genet. 10 (2): 205–10. PMID 6608795.
• Nishide T, Emi M, Nakamura Y, Matsubara K (1984). "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]". Gene. 28 (2): 263–70. PMID 6610603.CS1 maint: Multiple names: authors list (link)
• Seyama K, Nukiwa T, Takahashi K; et al. (1994). "Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes". J. Cancer Res. Clin. Oncol. 120 (4): 213–20. PMID 7507116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ragunath C, Sundar K, Ramasubbu N (2002). "Expression, characterization, and biochemical properties of recombinant human salivary amylase". Protein Expr. Purif. 24 (2): 202–11. doi:10.1006/prep.2001.1559. PMID 11858714.CS1 maint: Multiple names: authors list (link)
• Hokari S, Miura K, Koyama I; et al. (2002). "A restriction endonuclease assay for expression of human alpha-amylase isozymes". Clin. Chim. Acta. 322 (1–2): 113–6. PMID 12104089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramasubbu N, Ragunath C, Mishra PJ (2003). "Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase". J. Mol. Biol. 325 (5): 1061–76. PMID 12527308.CS1 maint: Multiple names: authors list (link)
• Kandra L, Gyémánt G, Remenyik J; et al. (2003). "Subsite mapping of human salivary alpha-amylase and the mutant Y151M". FEBS Lett. 544 (1–3): 194–8. PMID 12782315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)