AMY2A

Amylase, alpha 2A; pancreatic
File:PBB Protein AMY2A image.jpg PDB rendering based on 1b2y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b2y​, 1bsi​, 1c8q​, 1cpu​, 1hny​, 1jxj​, 1jxk​, 1kb3​, 1kbb​, 1kbk​, 1kgu​, 1kgw​, 1kgx​, 1mfu​, 1mfv​, 1nm9​, 1q4n​, 1smd​, 1u2y​, 1u30​, 1u33​, 1xcw​, 1xcx​, 1xd0​, 1xd1​, 1xgz​, 1xh0​, 1xh1​, 1xh2​, 1xv8​, 1z32​, 2cpu​, 3cpu​
Identifiers
Symbols	AMY2A ; AMY2; AMY2B; PA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20179
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amylase, alpha 2A; pancreatic, also known as AMY2A, is a human gene.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.

Further reading

• Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clin. Chim. Acta. 79 (1): 69–73. PMID 890964.
• Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase". Biochem. Cell Biol. 70 (10–11): 1105–14. PMID 1284286.CS1 maint: Multiple names: authors list (link)
• Groot PC, Mager WH, Henriquez NV; et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. PMID 2081604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishide T, Nakamura Y, Emi M; et al. (1986). "Primary structure of human salivary alpha-amylase gene". Gene. 41 (2–3): 299–304. PMID 2423416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horii A, Emi M, Tomita N; et al. (1988). "Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene". Gene. 60 (1): 57–64. PMID 2450054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gumucio DL, Wiebauer K, Caldwell RM; et al. (1988). "Concerted evolution of human amylase genes". Mol. Cell. Biol. 8 (3): 1197–205. PMID 2452973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Res. 16 (17): 8261–76. PMID 2458567.CS1 maint: Multiple names: authors list (link)
• Groot PC, Bleeker MJ, Pronk JC; et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. PMID 2788608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot PC, Bleeker MJ, Pronk JC; et al. (1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Res. 16 (10): 4724. PMID 3260028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wise RJ, Karn RC, Larsen SH; et al. (1986). "A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A.". Mol. Biol. Med. 2 (5): 307–22. PMID 6336237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somat. Cell Mol. Genet. 10 (2): 205–10. PMID 6608795.
• Nishide T, Emi M, Nakamura Y, Matsubara K (1984). "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]". Gene. 28 (2): 263–70. PMID 6610603.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Qian M, Haser R, Buisson G; et al. (1994). "The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution". Biochemistry. 33 (20): 6284–94. PMID 8193143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brayer GD, Luo Y, Withers SG (1996). "The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes". Protein Sci. 4 (9): 1730–42. PMID 8528071.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rydberg EH, Sidhu G, Vo HC; et al. (1999). "Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris". Protein Sci. 8 (3): 635–43. PMID 10091666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brayer GD, Sidhu G, Maurus R; et al. (2000). "Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques". Biochemistry. 39 (16): 4778–91. PMID 10769135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi medical journal. 22 (5): 410–5. PMID 11376382.
• Numao S, Maurus R, Sidhu G; et al. (2002). "Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase". Biochemistry. 41 (1): 215–25. PMID 11772019.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)