ANXA7

Annexin A7
Identifiers
Symbols	ANXA7 ; ANX7; SNX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 36149
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Annexin A7, also known as ANXA7, is a human gene.

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. The selection of poly(A) signals is independent of the mRNA splicing pattern. ~Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.

Further reading

• Creutz CE, Moss S, Edwardson JM; et al. (1992). "Differential recognition of secretory vesicles by annexins. European Molecular Biology Organization Course "Advanced Techniques for Studying Secretion"". Biochem. Biophys. Res. Commun. 184 (1): 347–52. PMID 1533123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magendzo K, Shirvan A, Cultraro C; et al. (1991). "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain". J. Biol. Chem. 266 (5): 3228–32. PMID 1825209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burns AL, Magendzo K, Shirvan A; et al. (1989). "Calcium channel activity of purified human synexin and structure of the human synexin gene". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3798–802. PMID 2542947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shirvan A, Srivastava M, Wang MG; et al. (1994). "Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10". Biochemistry. 33 (22): 6888–901. PMID 7515686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Selbert S, Fischer P, Pongratz D; et al. (1995). "Expression and localization of annexin VII (synexin) in muscle cells". J. Cell. Sci. 108 ( Pt 1): 85–95. PMID 7738119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang-Keck ZY, Srivastava M, Kozak CA; et al. (1994). "Genomic organization and chromosomal localization of the mouse synexin gene". Biochem. J. 301 ( Pt 3): 835–45. PMID 8053909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Brownawell AM, Creutz CE (1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". J. Biol. Chem. 272 (35): 22182–90. PMID 9268363.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clemen CS, Hofmann A, Zamparelli C, Noegel AA (2000). "Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts". J. Muscle Res. Cell. Motil. 20 (7): 669–79. PMID 10672515.CS1 maint: Multiple names: authors list (link)
• Caohuy H, Pollard HB (2001). "Activation of annexin 7 by protein kinase C in vitro and in vivo". J. Biol. Chem. 276 (16): 12813–21. doi:10.1074/jbc.M008482200. PMID 11278415.
• Srivastava M, Bubendorf L, Srikantan V; et al. (2001). "ANX7, a candidate tumor suppressor gene for prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4575–80. doi:10.1073/pnas.071055798. PMID 11287641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clemen CS, Herr C, Lie AA; et al. (2001). "Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution". Neuroreport. 12 (6): 1139–44. PMID 11338180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu F, Finley RL, Raz A, Kim HR (2002). "Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation". J. Biol. Chem. 277 (18): 15819–27. doi:10.1074/jbc.M200154200. PMID 11839755.CS1 maint: Multiple names: authors list (link)
• Caohuy H, Pollard HB (2002). "Protein kinase C and guanosine triphosphate combine to potentiate calcium-dependent membrane fusion driven by annexin 7". J. Biol. Chem. 277 (28): 25217–25. doi:10.1074/jbc.M202452200. PMID 11994295.
• Satoh H, Nakano Y, Shibata H, Maki M (2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochim. Biophys. Acta. 1600 (1–2): 61–7. PMID 12445460.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castle J, Garrett-Engele P, Armour CD; et al. (2004). "Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing". Genome Biol. 4 (10): R66. doi:10.1186/gb-2003-4-10-r66. PMID 14519201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)