AP1B1

Adaptor-related protein complex 1, beta 1 subunit
File:PBB Protein AP1B1 image.jpg PDB rendering based on 1w63.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1w63​
Identifiers
Symbols	AP1B1 ; ADTB1; AP105A; BAM22; CLAPB2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21972
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adaptor-related protein complex 1, beta 1 subunit, also known as AP1B1, is a human gene.

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.

Further reading

• Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.CS1 maint: Multiple names: authors list (link)
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. PMID 12836198.
• Peyrard M, Fransson I, Xie YG; et al. (1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum. Mol. Genet. 3 (8): 1393–9. PMID 7987321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peyrard M, Pan HQ, Kedra D; et al. (1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics. 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID 8812422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim DS, Kirsch DG, Canman CE; et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. PMID 9707615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takatsu H, Sakurai M, Shin HW; et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. 273 (38): 24693–700. PMID 9733768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. PMID 9736718.CS1 maint: Multiple names: authors list (link)
• Bresnahan PA, Yonemoto W, Ferrell S; et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. PMID 9811606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greenberg M, DeTulleo L, Rapoport I; et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. PMID 9811611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laporte SA, Oakley RH, Zhang J; et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. PMID 10097102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. PMID 10535737.CS1 maint: Multiple names: authors list (link)
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.CS1 maint: Multiple names: authors list (link)
• Lai MM, Luo HR, Burnett PE; et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakagawa T, Setou M, Seog D; et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. PMID 11106728.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takatsu H, Futatsumori M, Yoshino K; et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Mol. Biol. Cell. 12 (7): 1925–35. PMID 11451993.
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.CS1 maint: Multiple names: authors list (link)