AP1S1

Adaptor-related protein complex 1, sigma 1 subunit
File:PBB Protein AP1S1 image.jpg PDB rendering based on 1w63.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1w63​
Identifiers
Symbols	AP1S1 ; AP19; CLAPS1; SIGMA1A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20342
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adaptor-related protein complex 1, sigma 1 subunit, also known as AP1S1, is a human gene.

The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.

Further reading

• Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.CS1 maint: Multiple names: authors list (link)
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. PMID 12836198.
• Kirchhausen T, Davis AC, Frucht S; et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. PMID 2040623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peyrard M, Parveneh S, Lagercrantz S; et al. (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takatsu H, Sakurai M, Shin HW; et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. 273 (38): 24693–700. PMID 9733768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. PMID 9736718.CS1 maint: Multiple names: authors list (link)
• Bresnahan PA, Yonemoto W, Ferrell S; et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. PMID 9811606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greenberg M, DeTulleo L, Rapoport I; et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. PMID 9811611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L; et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. PMID 9882340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. PMID 10535737.CS1 maint: Multiple names: authors list (link)
• Wyss S, Berlioz-Torrent C, Boge M; et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMID 11222723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boehm M, Aguilar RC, Bonifacino JS (2002). "Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)". EMBO J. 20 (22): 6265–76. doi:10.1093/emboj/20.22.6265. PMID 11707398.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janvier K, Craig H, Hitchin D; et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes". J. Biol. Chem. 278 (10): 8725–32. doi:10.1074/jbc.M210115200. PMID 12486136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)