APOBEC1

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Identifiers
Symbols	APOBEC1 ; APOBEC-1; BEDP; CDAR1; HEPR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1243
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, also known as APOBEC1, is a human gene.

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. PMID 12683974.CS1 maint: Multiple names: authors list (link)
• Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966.
• Espinosa R, Funahashi T, Hadjiagapiou C; et al. (1995). "Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1". Genomics. 24 (2): 414–5. doi:10.1006/geno.1994.1645. PMID 7698776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Navaratnam N, Bhattacharya S, Fujino T; et al. (1995). "Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site". Cell. 81 (2): 187–95. PMID 7736571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau PP, Zhu HJ, Baldini A; et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522–6. PMID 8078915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hadjiagapiou C, Giannoni F, Funahashi T; et al. (1994). "Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein". Nucleic Acids Res. 22 (10): 1874–9. PMID 8208612.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morrison JR, Pászty C, Stevens ME; et al. (1996). "Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7154–9. PMID 8692961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau PP, Zhu HJ, Nakamuta M, Chan L (1997). "Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing". J. Biol. Chem. 272 (3): 1452–5. PMID 8999813.CS1 maint: Multiple names: authors list (link)
• Oka K, Kobayashi K, Sullivan M; et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice". J. Biol. Chem. 272 (3): 1456–60. PMID 8999814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirano K, Min J, Funahashi T; et al. (1997). "Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide". J. Lipid Res. 38 (5): 847–59. PMID 9186903.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujino T, Navaratnam N, Scott J (1998). "Human apolipoprotein B RNA editing deaminase gene (APOBEC1)". Genomics. 47 (2): 266–75. doi:10.1006/geno.1997.5110. PMID 9479499.CS1 maint: Multiple names: authors list (link)
• Mehta A, Kinter MT, Sherman NE, Driscoll DM (2000). "Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA". Mol. Cell. Biol. 20 (5): 1846–54. PMID 10669759.CS1 maint: Multiple names: authors list (link)
• Lellek H, Kirsten R, Diehl I; et al. (2000). "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex". J. Biol. Chem. 275 (26): 19848–56. doi:10.1074/jbc.M001786200. PMID 10781591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanc V, Navaratnam N, Henderson JO; et al. (2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem. Biophys. Res. Commun. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.CS1 maint: Multiple names: authors list (link)
• Anant S, Henderson JO, Mukhopadhyay D; et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau PP, Villanueva H, Kobayashi K; et al. (2002). "A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing". J. Biol. Chem. 276 (49): 46445–52. doi:10.1074/jbc.M109215200. PMID 11584023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anant S, Mukhopadhyay D, Sankaranand V; et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing". Am. J. Physiol., Cell Physiol. 281 (6): C1904–16. PMID 11698249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mukhopadhyay D, Anant S, Lee RM; et al. (2002). "C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme". Am. J. Hum. Genet. 70 (1): 38–50. PMID 11727199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dance GS, Sowden MP, Cartegni L; et al. (2002). "Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing". J. Biol. Chem. 277 (15): 12703–9. doi:10.1074/jbc.M111337200. PMID 11815617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)