APOM
| Apolipoprotein M | |||||||||||
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| Symbols | APOM ; G3a; HSPC336; MGC22400; NG20 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10308 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Apolipoprotein M, also known as APOM, is a human gene.[1]
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.[1]
References
Further reading
- Albertella MR, Jones H, Thomson W; et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)". Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
- Xu N, Dahlbäck B (1999). "A novel human apolipoprotein (apoM)". J. Biol. Chem. 274 (44): 31286–90. PMID 10531326.
- Duan J, Dahlbäck B, Villoutreix BO (2001). "Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis". FEBS Lett. 499 (1–2): 127–32. PMID 11418126.
- Xu N, Zhang XY, Dong X; et al. (2002). "Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells". Biochem. Biophys. Res. Commun. 292 (4): 944–50. doi:10.1006/bbrc.2002.6755. PMID 11944906.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Zhang XY, Dong X, Zheng L; et al. (2003). "Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization". Acta Histochem. 105 (1): 67–72. PMID 12666989.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Richter S, Shih DQ, Pearson ER; et al. (2004). "Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels". Diabetes. 52 (12): 2989–95. PMID 14633861.
- Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
- Zhang XY, Jiao GQ, Hurtig M; et al. (2005). "Expression pattern of apolipoprotein M during mouse and human embryogenesis". Acta Histochem. 106 (2): 123–8. doi:10.1016/j.acthis.2003.11.004. PMID 15147633.
- Kabbara A, Payet N, Cottel D; et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Xu N, Nilsson-Ehle P, Ahrén B (2005). "Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects". J. Nutr. Biochem. 15 (10): 579–82. doi:10.1016/j.jnutbio.2004.03.001. PMID 15542348.
- Luo G, Hurtig M, Zhang X; et al. (2005). "Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells". Biochim. Biophys. Acta. 1734 (2): 198–202. doi:10.1016/j.bbalip.2005.02.005. PMID 15904876.
- Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
- Niu N, Zhu X, Liu Y; et al. (2007). "Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese". Diabetes Metab. Res. Rev. 23 (1): 21–5. doi:10.1002/dmrr.641. PMID 16572495.
- Christoffersen C, Nielsen LB, Axler O; et al. (2006). "Isolation and characterization of human apolipoprotein M-containing lipoproteins". J. Lipid Res. 47 (8): 1833–43. doi:10.1194/jlr.M600055-JLR200. PMID 16682745.
- Karlsson H, Lindqvist H, Tagesson C, Lindahl M (2006). "Characterization of apolipoprotein M isoforms in low-density lipoprotein". J. Proteome Res. 5 (10): 2685–90. doi:10.1021/pr060180x. PMID 17022639.
- Xu X, Ye Q, Xu N; et al. (2007). "Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver". Transplant. Proc. 38 (9): 2769–73. doi:10.1016/j.transproceed.2006.08.133. PMID 17112825.
- Ahnström J, Faber K, Axler O, Dahlbäck B (2007). "Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M.". J. Lipid Res. 48 (8): 1754–62. doi:10.1194/jlr.M700103-JLR200. PMID 17525477.
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