ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Identifiers
Symbols	ARFGEF2 ; BIG2; FLJ23723; dJ1164I10.1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21287
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), also known as ARFGEF2, is a human gene.

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.

Further reading

• Togawa A, Morinaga N, Ogasawara M; et al. (1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". J. Biol. Chem. 274 (18): 12308–15. PMID 10212200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaji R, Adamik R, Takeda K; et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. PMID 10716990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamei Y, Takeda Y, Teramoto K; et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". Meth. Enzymol. 345: 397–404. PMID 11665623.CS1 maint: Multiple names: authors list (link)
• Shinotsuka C, Yoshida Y, Kawamoto K; et al. (2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". J. Biol. Chem. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shinotsuka C, Waguri S, Wakasugi M; et al. (2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochem. Biophys. Res. Commun. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Adamik R, Pacheco-Rodriguez G; et al. (2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMID 12571360.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sheen VL, Ganesh VS, Topcu M; et al. (2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nat. Genet. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu KF, Shen X, Li H; et al. (2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2784–9. doi:10.1073/pnas.0409871102. PMID 15705715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu J, Tiao G, Folkerth R; et al. (2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". J. Comp. Neurol. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Islam A, Shen X, Hiroi T; et al. (2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". J. Biol. Chem. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMID 17360629.CS1 maint: Multiple names: authors list (link)