Actinin alpha 4

Actinin, alpha 4
PDB rendering based on 1wlx.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wlx​, 2eyi​, 2eyn​
Identifiers
Symbols	ACTN4 ; DKFZp686K23158; FSGS; FSGS1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55857
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Actinin, alpha 4, also known as ACTN4, is a human gene.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network". J. Cell. Sci. 101 ( Pt 2): 403–14. PMID 1629252.
• Otey CA, Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. PMID 2116421.CS1 maint: Multiple names: authors list (link)
• Pavalko FM, LaRoche SM (1993). "Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". J. Immunol. 151 (7): 3795–807. PMID 8104223.
• Mathis BJ, Kim SH, Calabrese K; et al. (1998). "A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13". Kidney Int. 53 (2): 282–6. doi:10.1046/j.1523-1755.1998.00828.x. PMID 9461087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Honda K, Yamada T, Endo R; et al. (1998). "Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion". J. Cell Biol. 140 (6): 1383–93. PMID 9508771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang H, Wang L, Kao S; et al. (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. PMID 10556093.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nikolopoulos SN, Spengler BA, Kisselbach K; et al. (2000). "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells". Oncogene. 19 (3): 380–6. doi:10.1038/sj.onc.1203310. PMID 10656685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• El-Husseini AE, Kwasnicka D, Yamada T; et al. (2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. PMID 10673389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaplan JM, Kim SH, North KN; et al. (2000). "Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis". Nat. Genet. 24 (3): 251–6. doi:10.1038/73456. PMID 10700177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15): 11100–5. PMID 10753915.CS1 maint: Multiple names: authors list (link)
• Holliday LS, Lu M, Lee BS; et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site". J. Biol. Chem. 275 (41): 32331–7. doi:10.1074/jbc.M004795200. PMID 10915794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walikonis RS, Oguni A, Khorosheva EM; et al. (2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. PMID 11160423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Echchakir H, Mami-Chouaib F, Vergnon I; et al. (2001). "A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma". Cancer Res. 61 (10): 4078–83. PMID 11358829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu F, Zhao R, Peng Y; et al. (2001). "Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities". J. Biol. Chem. 276 (31): 29479–84. doi:10.1074/jbc.M104428200. PMID 11382784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hüttelmaier S, Illenberger S, Grosheva I; et al. (2002). "Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins". J. Cell Biol. 155 (5): 775–86. doi:10.1083/jcb.200105044. PMID 11724819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Renoult C, Blondin L, Fattoum A; et al. (2002). "Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin". Eur. J. Biochem. 268 (23): 6165–75. PMID 11733011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez AM, Otey C, Edlund M, Jones JC (2002). "Interactions of a hemidesmosome component and actinin family members". J. Cell. Sci. 114 (Pt 23): 4197–206. PMID 11739652.CS1 maint: Multiple names: authors list (link)
• Lukoyanova N, VanLoock MS, Orlova A; et al. (2002). "Each actin subunit has three nebulin binding sites: implications for steric blocking". Curr. Biol. 12 (5): 383–8. PMID 11882289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim JH, Lee-Kwon W, Park JB; et al. (2002). "Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis". J. Biol. Chem. 277 (26): 23714–24. doi:10.1074/jbc.M200835200. PMID 11948184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)