BCL2L14

BCL2-like 14 (apoptosis facilitator)
Identifiers
Symbols	BCL2L14 ; BCLG
External IDs	Template:OMIM5 Template:MGI HomoloGene: 49840
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BCL2-like 14 (apoptosis facilitator), also known as BCL2L14, is a human gene.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo B, Godzik A, Reed JC (2001). "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family". J. Biol. Chem. 276 (4): 2780–5. doi:10.1074/jbc.M005889200. PMID 11054413.CS1 maint: Multiple names: authors list (link)
• Montpetit A, Boily G, Sinnett D (2002). "A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus". Eur. J. Hum. Genet. 10 (1): 62–71. doi:10.1038/sj.ejhg.5200766. PMID 11896457.CS1 maint: Multiple names: authors list (link)
• Kutsenko AS, Gizatullin RZ, Al-Amin AN; et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. PMID 12136098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozalp SS, Yalcin OT, Tanir HM; et al. (2003). "Bcl-2 expression in preinvasive and invasive cervical lesions". Eur. J. Gynaecol. Oncol. 23 (5): 419–22. PMID 12440815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montpetit A, Larose J, Boily G; et al. (2004). "Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia". Leukemia. 18 (9): 1499–504. doi:10.1038/sj.leu.2403441. PMID 15284860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soung YH, Lee JW, Park WS; et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder". Pathology. 38 (1): 33–4. doi:10.1080/00313020500455811. PMID 16484005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin ML, Park JH, Nishidate T; et al. (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMID 17280616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoo NJ, Soung YH, Lee SH; et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas". Tumori. 93 (2): 195–7. PMID 17557568.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)