BDP1

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Identifiers
Symbols	BDP1 ; TFIIIB90; DKFZp686C01233; DKFZp686K0831; HSA238520; KIAA1241; KIAA1689; TAF3B1; TFC5; TFIIIB; TFIIIB150; TFNR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 34582
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, also known as BDP1, is a human gene.

The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.

Further reading

• Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. PMID 9169441.CS1 maint: Multiple names: authors list (link)
• Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. PMID 9171375.
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schramm L, Pendergrast PS, Sun Y, Hernandez N (2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. PMID 11040218.CS1 maint: Multiple names: authors list (link)
• Kelter AR, Herchenbach J, Wirth B (2001). "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1". Genomics. 70 (3): 315–26. doi:10.1006/geno.2000.6396. PMID 11161782.CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Hattori A; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. PMID 11214970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu P, Wu S, Hernandez N (2003). "A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2". Mol. Cell. 12 (3): 699–709. PMID 14527415.CS1 maint: Multiple names: authors list (link)
• Fairley JA, Scott PH, White RJ (2003). "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo". EMBO J. 22 (21): 5841–50. doi:10.1093/emboj/cdg544. PMID 14592981.CS1 maint: Multiple names: authors list (link)
• Weser S, Gruber C, Hafner HM; et al. (2004). "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity". J. Biol. Chem. 279 (26): 27022–9. doi:10.1074/jbc.M312790200. PMID 15096501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu P, Samudre K, Wu S; et al. (2004). "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression". Mol. Cell. 16 (1): 81–92. doi:10.1016/j.molcel.2004.09.008. PMID 15469824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schoenen F, Wirth B (2006). "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB". Biol. Chem. 387 (3): 277–84. doi:10.1515/BC.2006.037. PMID 16542149.
• Johnson SS, Zhang C, Fromm J; et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)