BRD4

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Bromodomain containing 4
PDB rendering based on 2oss.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols BRD4 ; CAP; HUNKI; MCAP
External IDs Template:OMIM5 Template:MGI HomoloGene: 84762
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Bromodomain containing 4, also known as BRD4, is a human gene.[1]

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: BRD4 bromodomain containing 4".

Further reading

  • Dey A, Ellenberg J, Farina A; et al. (2000). "A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition". Mol. Cell. Biol. 20 (17): 6537–49. PMID 10938129.
  • French CA, Miyoshi I, Aster JC; et al. (2001). "BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)". Am. J. Pathol. 159 (6): 1987–92. PMID 11733348.
  • Maruyama T, Farina A, Dey A; et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • French CA, Miyoshi I, Kubonishi I; et al. (2003). "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma". Cancer Res. 63 (2): 304–7. PMID 12543779.
  • Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
  • You J, Croyle JL, Nishimura A; et al. (2004). "Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes". Cell. 117 (3): 349–60. PMID 15109495.
  • Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Farina A, Hattori M, Qin J; et al. (2004). "Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization". Mol. Cell. Biol. 24 (20): 9059–69. doi:10.1128/MCB.24.20.9059-9069.2004. PMID 15456879.
  • Baxter MK, McPhillips MG, Ozato K, McBride AA (2005). "The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4". J. Virol. 79 (8): 4806–18. doi:10.1128/JVI.79.8.4806-4818.2005. PMID 15795266.
  • Haruki N, Kawaguchi KS, Eichenberger S; et al. (2006). "Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro". J. Med. Genet. 42 (7): 558–64. doi:10.1136/jmg.2004.029686. PMID 15994877.
  • Schweiger MR, You J, Howley PM (2006). "Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function". J. Virol. 80 (9): 4276–85. doi:10.1128/JVI.80.9.4276-4285.2006. PMID 16611886.
  • Wu SY, Lee AY, Hou SY; et al. (2006). "Brd4 links chromatin targeting to HPV transcriptional silencing". Genes Dev. 20 (17): 2383–96. doi:10.1101/gad.1448206. PMID 16921027.
  • You J, Srinivasan V, Denis GV; et al. (2006). "Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes". J. Virol. 80 (18): 8909–19. doi:10.1128/JVI.00502-06. PMID 16940503.
  • Sénéchal H, Poirier GG, Coulombe B; et al. (2007). "Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4". Virology. 358 (1): 10–7. doi:10.1016/j.virol.2006.08.035. PMID 17023018.
  • Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Abbate EA, Voitenleitner C, Botchan MR (2007). "Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association". Mol. Cell. 24 (6): 877–89. doi:10.1016/j.molcel.2006.11.002. PMID 17189190.
  • Schweiger MR, Ottinger M, You J, Howley PM (2007). "Brd4-independent transcriptional repression function of the papillomavirus e2 proteins". J. Virol. 81 (18): 9612–22. doi:10.1128/JVI.00447-07. PMID 17626100.
  • Bisgrove DA, Mahmoudi T, Henklein P, Verdin E (2007). "Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription". Proc. Natl. Acad. Sci. U.S.A. 104 (34): 13690–5. doi:10.1073/pnas.0705053104. PMID 17690245.

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