BRF1 (gene)

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Identifiers
Symbols	BRF1 ; BRF; FLJ42674; FLJ43034; GTF3B; MGC105048; TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90; hBRF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1161
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae), also known as BRF1, is a human gene.

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.

Further reading

• Wang Z, Roeder RG (1995). "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7026–30. PMID 7624363.
• Mital R, Kobayashi R, Hernandez N (1997). "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB". Mol. Cell. Biol. 16 (12): 7031–42. PMID 8943358.CS1 maint: Multiple names: authors list (link)
• Chesnokov I, Chu WM, Botchan MR, Schmid CW (1997). "p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner". Mol. Cell. Biol. 16 (12): 7084–8. PMID 8943363.CS1 maint: Multiple names: authors list (link)
• Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. PMID 9169441.CS1 maint: Multiple names: authors list (link)
• Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. PMID 9171375.
• Sutcliffe JE, Cairns CA, McLees A; et al. (1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. 19 (6): 4255–61. PMID 10330166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMID 10373544.CS1 maint: Multiple names: authors list (link)
• Hsieh YJ, Kundu TK, Wang Z; et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. PMID 10523658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCulloch V, Hardin P, Peng W; et al. (2000). "Alternatively spliced hBRF variants function at different RNA polymerase III promoters". EMBO J. 19 (15): 4134–43. doi:10.1093/emboj/19.15.4134. PMID 10921893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johnston IM, Allison SJ, Morton JP; et al. (2002). "CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells". Mol. Cell. Biol. 22 (11): 3757–68. PMID 11997511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cabart P, Murphy S (2002). "Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter". J. Biol. Chem. 277 (30): 26831–8. doi:10.1074/jbc.M203119200. PMID 12016223.
• Willis IM (2002). "A universal nomenclature for subunits of the RNA polymerase III transcription initiation factor TFIIIB". Genes Dev. 16 (11): 1337–8. PMID 12066800.
• Stoecklin G, Colombi M, Raineri I; et al. (2002). "Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover". EMBO J. 21 (17): 4709–18. PMID 12198173.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weser S, Riemann J, Seifart KH, Meissner W (2003). "Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene". Nucleic Acids Res. 31 (9): 2408–16. PMID 12711686.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidlin M, Lu M, Leuenberger SA; et al. (2005). "The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.". EMBO J. 23 (24): 4760–9. doi:10.1038/sj.emboj.7600477. PMID 15538381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)