BTG2

BTG family, member 2
Identifiers
Symbols	BTG2 ; PC3; MGC126063; MGC126064; TIS21
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31406
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BTG family, member 2, also known as BTG2, is a human gene.

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.

Further reading

• Puisieux A, Magaud JP (1999). "[Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis.]". Bulletin du cancer. 86 (4): 358–64. PMID 10341341.
• Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. doi:10.1002/jcp.1062. PMID 11267995.
• Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett. 497 (2–3): 67–72. PMID 11377414.CS1 maint: Multiple names: authors list (link)
• Fletcher BS, Lim RW, Varnum BC; et al. (1991). "Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters". J. Biol. Chem. 266 (22): 14511–8. PMID 1713584.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin WJ, Gary JD, Yang MC; et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". J. Biol. Chem. 271 (25): 15034–44. PMID 8663146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montagnoli A, Guardavaccaro D, Starace G, Tirone F (1997). "Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition". Cell Growth Differ. 7 (10): 1327–36. PMID 8891336.CS1 maint: Multiple names: authors list (link)
• Rouault JP, Falette N, Guéhenneux F; et al. (1997). "Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway". Nat. Genet. 14 (4): 482–6. doi:10.1038/ng1296-482. PMID 8944033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rouault JP, Prévôt D, Berthet C; et al. (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex". J. Biol. Chem. 273 (35): 22563–9. PMID 9712883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walden PD, Lefkowitz GK, Ficazzola M; et al. (1999). "Identification of genes associated with stromal hyperplasia and glandular atrophy of the prostate by mRNA differential display". Exp. Cell Res. 245 (1): 19–26. doi:10.1006/excr.1998.4237. PMID 9828097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iacopetti P, Michelini M, Stuckmann I; et al. (1999). "Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4639–44. PMID 10200315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prévôt D, Voeltzel T, Birot AM; et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. PMID 10617598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guardavaccaro D, Corrente G, Covone F; et al. (2000). "Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription". Mol. Cell. Biol. 20 (5): 1797–815. PMID 10669755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prévôt D, Morel AP, Voeltzel T; et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1". Biochem. J. 354 (Pt 3): 635–43. PMID 11237868.CS1 maint: Multiple names: authors list (link)
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045.CS1 maint: Multiple names: authors list (link)
• Ficazzola MA, Fraiman M, Gitlin J; et al. (2001). "Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis". Carcinogenesis. 22 (8): 1271–9. PMID 11470758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duriez C, Falette N, Audoynaud C; et al. (2002). "The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene". Gene. 282 (1–2): 207–14. PMID 11814693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)