BTRC (gene)

Beta-transducin repeat containing
PDB rendering based on 1p22.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1p22​
Identifiers
Symbols	BTRC ; BETA-TRCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 39330
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Beta-transducin repeat containing, also known as BTRC, is a human gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Further reading

• Maniatis T (1999). "A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways". Genes Dev. 13 (5): 505–10. PMID 10072378.
• Li L, Li HS, Pauza CD; et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Margottin F, Bour SP, Durand H; et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. PMID 9660940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yaron A, Hatzubai A, Davis M; et al. (1999). "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase". Nature. 396 (6711): 590–4. doi:10.1038/25159. PMID 9859996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winston JT, Strack P, Beer-Romero P; et al. (1999). "The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro". Genes Dev. 13 (3): 270–83. PMID 9990852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spencer E, Jiang J, Chen ZJ (1999). "Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP". Genes Dev. 13 (3): 284–94. PMID 9990853.CS1 maint: Multiple names: authors list (link)
• Kitagawa M, Hatakeyama S, Shirane M; et al. (1999). "An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin". EMBO J. 18 (9): 2401–10. doi:10.1093/emboj/18.9.2401. PMID 10228155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujiwara T, Suzuki M, Tanigami A; et al. (1999). "The BTRC gene, encoding a human F-box/WD40-repeat protein, maps to chromosome 10q24-q25". Genomics. 58 (1): 104–5. doi:10.1006/geno.1999.5792. PMID 10331953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu C, Ghosh S (1999). "beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta". J. Biol. Chem. 274 (42): 29591–4. PMID 10514424.
• Cenciarelli C, Chiaur DS, Guardavaccaro D; et al. (1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stone DM, Murone M, Luoh S; et al. (2000). "Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli". J. Cell. Sci. 112 ( Pt 23): 4437–48. PMID 10564661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Chiba T, Suzuki T; et al. (2000). "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination". J. Biol. Chem. 275 (4): 2877–84. PMID 10644755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Read MA, Brownell JE, Gladysheva TB; et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Mol. Cell. Biol. 20 (7): 2326–33. PMID 10713156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sadot E, Simcha I, Iwai K; et al. (2000). "Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system". Oncogene. 19 (16): 1992–2001. doi:10.1038/sj.onc.1203519. PMID 10803460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiaur DS, Murthy S, Cenciarelli C; et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. PMID 10828603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orian A, Gonen H, Bercovich B; et al. (2000). "SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase". EMBO J. 19 (11): 2580–91. doi:10.1093/emboj/19.11.2580. PMID 10835356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strack P, Caligiuri M, Pelletier M; et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleijnen MF, Shih AH, Zhou P; et al. (2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Mol. Cell. 6 (2): 409–19. PMID 10983987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)