CACYBP

Calcyclin binding protein
PDB rendering based on 1x5m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x5m​, 2a26​
Identifiers
Symbols	CACYBP ; SIP; GIG5; MGC87971; PNAS-107; RP1-102G20.6; S100A6BP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7649
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcyclin binding protein, also known as CACYBP, is a human gene.

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. 7 (5): 915–26. PMID 11389839.
• Filipek A, Jastrzebska B, Nowotny M; et al. (2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells". J. Biol. Chem. 277 (23): 21103–9. doi:10.1074/jbc.M111010200. PMID 11927578.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu WX, Wu J, Zhao Z; et al. (2003). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (2): 181–6. PMID 12006993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.CS1 maint: Multiple names: authors list (link)
• Matsuzawa S, Li C, Ni CZ; et al. (2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J. Biol. Chem. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu J, Tan X, Peng X; et al. (2004). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells". J. Biochem. Mol. Biol. 36 (4): 354–8. PMID 12895292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santelli E, Leone M, Li C; et al. (2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". J. Biol. Chem. 280 (40): 34278–87. doi:10.1074/jbc.M506707200. PMID 16085652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun S, Ning X, Liu J; et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochem. Biophys. Res. Commun. 356 (4): 864–71. doi:10.1016/j.bbrc.2007.03.080. PMID 17400182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)