CAPN10

Calpain 10
Identifiers
Symbols	CAPN10 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 36323
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calpain 10, also known as CAPN10, is a human gene.

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.

Further reading

• Sorimachi H, Ishiura S, Suzuki K (1998). "Structure and physiological function of calpains". Biochem. J. 328 ( Pt 3): 721–32. PMID 9396712.CS1 maint: Multiple names: authors list (link)
• Cox NJ, Hayes MG, Roe CA; et al. (2004). "Linkage of calpain 10 to type 2 diabetes: the biological rationale". Diabetes. 53 Suppl 1: S19–25. PMID 14749261.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Turner MD, Cassell PG, Hitman GA (2006). "Calpain-10: from genome search to function". Diabetes Metab. Res. Rev. 21 (6): 505–14. doi:10.1002/dmrr.578. PMID 16028216.CS1 maint: Multiple names: authors list (link)
• Horikawa Y (2007). "Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes". Endocr. J. 53 (5): 567–76. PMID 16873988.
• Horikawa Y, Oda N, Cox NJ; et al. (2000). "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus". Nat. Genet. 26 (2): 163–75. doi:10.1038/79876. PMID 11017071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baier LJ, Permana PA, Yang X; et al. (2000). "A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance". J. Clin. Invest. 106 (7): R69–73. PMID 11018080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Nakayama M, Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. PMID 11347906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma H, Fukiage C, Kim YH; et al. (2001). "Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization". J. Biol. Chem. 276 (30): 28525–31. doi:10.1074/jbc.M100603200. PMID 11375982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Evans JC, Frayling TM, Cassell PG; et al. (2001). "Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom". Am. J. Hum. Genet. 69 (3): 544–52. PMID 11481585.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai HJ, Sun G, Weeks DE; et al. (2002). "Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association". Am. J. Hum. Genet. 69 (6): 1236–44. PMID 11704924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woollard JR, Rothschild MF (2002). "Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26". Anim. Genet. 32 (6): 393. PMID 11736815.
• Xiang K, Fang Q, Zheng T; et al. (2002). "[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 18 (6): 426–30. PMID 11774208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elbein SC, Chu W, Ren Q; et al. (2002). "Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians". J. Clin. Endocrinol. Metab. 87 (2): 650–4. PMID 11836299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daimon M, Oizumi T, Saitoh T; et al. (2002). "Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese". Diabetes Res. Clin. Pract. 56 (2): 147–52. PMID 11891023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fullerton SM, Bartoszewicz A, Ybazeta G; et al. (2002). "Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus". Am. J. Hum. Genet. 70 (5): 1096–106. PMID 11891618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffstedt J, Rydén M, Löfgren P; et al. (2002). "Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells". Diabetologia. 45 (2): 276–82. doi:10.1007/s00125-001-0732-2. PMID 11935160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malecki MT, Moczulski DK, Klupa T; et al. (2002). "Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population". Eur. J. Endocrinol. 146 (5): 695–9. PMID 11980626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun HX, Zhang KX, Du WN; et al. (2002). "Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China". Biomed. Environ. Sci. 15 (1): 75–82. PMID 12046551.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haddad L, Evans JC, Gharani N; et al. (2002). "Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome". J. Clin. Endocrinol. Metab. 87 (6): 2606–10. PMID 12050223.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)