CASC3

Cancer susceptibility candidate 3
PDB rendering based on 2hyi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hyi​, 2j0q​, 2j0s​, 2j0u​
Identifiers
Symbols	CASC3 ; BTZ; MLN51
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7208
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cancer susceptibility candidate 3, also known as CASC3, is a human gene.

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.

Further reading

• Tomasetto C, Régnier C, Moog-Lutz C; et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Varis A, Wolf M, Monni O; et al. (2002). "Targets of gene amplification and overexpression at 17q in gastric cancer". Cancer Res. 62 (9): 2625–9. PMID 11980659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Degot S, Régnier CH, Wendling C; et al. (2002). "Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer". Oncogene. 21 (28): 4422–34. doi:10.1038/sj.onc.1205611. PMID 12080473.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macchi P, Kroening S, Palacios IM; et al. (2003). "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner". J. Neurosci. 23 (13): 5778–88. PMID 12843282.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature. 427 (6976): 753–7. doi:10.1038/nature02351. PMID 14973490.CS1 maint: Multiple names: authors list (link)
• Degot S, Le Hir H, Alpy F; et al. (2004). "Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module". J. Biol. Chem. 279 (32): 33702–15. doi:10.1074/jbc.M402754200. PMID 15166247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim YK, Furic L, Desgroseillers L, Maquat LE (2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326.CS1 maint: Multiple names: authors list (link)
• Ballut L, Marchadier B, Baguet A; et al. (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity". Nat. Struct. Mol. Biol. 12 (10): 861–9. doi:10.1038/nsmb990. PMID 16170325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tange TØ, Shibuya T, Jurica MS, Moore MJ (2006). "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core". RNA. 11 (12): 1869–83. doi:10.1261/rna.2155905. PMID 16314458.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibuya T, Tange TØ, Stroupe ME, Moore MJ (2006). "Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay". RNA. 12 (3): 360–74. doi:10.1261/rna.2190706. PMID 16495234.CS1 maint: Multiple names: authors list (link)
• Andersen CB, Ballut L, Johansen JS; et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA". Science. 313 (5795): 1968–72. doi:10.1126/science.1131981. PMID 16931718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baguet A, Degot S, Cougot N; et al. (2007). "The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly". J. Cell. Sci. 120 (Pt 16): 2774–84. doi:10.1242/jcs.009225. PMID 17652158.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)