CCL3L1

Chemokine (C-C motif) ligand 3-like 1
File:PBB Protein CCL3L1 image.jpg PDB rendering based on 1b50.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b50​, 1b53​
Identifiers
Symbols	CCL3L1 ; 464.2; D17S1718; G0S19-2; LD78; LD78BETA; MGC104178; MGC12815; SCYA3L; SCYA3L1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2242
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chemokine (C-C motif) ligand 3-like 1, also known as CCL3L1, is a human gene.

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene and a partial pseudogene. This record represents the more telomeric full-length gene.

Further reading

• Hirashima M, Ono T, Nakao M; et al. (1993). "Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17". DNA Seq. 3 (4): 203–12. PMID 1296815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakao M, Nomiyama H, Shimada K (1990). "Structures of human genes coding for cytokine LD78 and their expression". Mol. Cell. Biol. 10 (7): 3646–58. PMID 1694014.CS1 maint: Multiple names: authors list (link)
• Irving SG, Zipfel PF, Balke J; et al. (1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. PMID 1972563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blum S, Forsdyke RE, Forsdyke DR (1991). "Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation". DNA Cell Biol. 9 (8): 589–602. PMID 2271120.CS1 maint: Multiple names: authors list (link)
• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naruse K, Ueno M, Satoh T; et al. (1997). "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2". Genomics. 34 (2): 236–40. doi:10.1006/geno.1996.0274. PMID 8661057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nibbs RJ, Yang J, Landau NR; et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity". J. Biol. Chem. 274 (25): 17478–83. PMID 10364178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xin X, Shioda T, Kato A; et al. (1999). "Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-1alpha/LD78alpha". FEBS Lett. 457 (2): 219–22. PMID 10471782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Proost P, Menten P, Struyf S; et al. (2000). "Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist". Blood. 96 (5): 1674–80. PMID 10961862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambeir AM, Proost P, Durinx C; et al. (2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family". J. Biol. Chem. 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Struyf S, Menten P, Lenaerts JP; et al. (2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. PMID 11449371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyakawa T, Obaru K, Maeda K; et al. (2002). "Identification of amino acid residues critical for LD78beta, a variant of human macrophage inflammatory protein-1alpha, binding to CCR5 and inhibition of R5 human immunodeficiency virus type 1 replication". J. Biol. Chem. 277 (7): 4649–55. doi:10.1074/jbc.M109198200. PMID 11734558.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". Eur. J. Immunol. 32 (10): 3016–26. doi:10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D. PMID 12355456.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Modi WS (2004). "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12". Genomics. 83 (4): 735–8. doi:10.1016/j.ygeno.2003.09.019. PMID 15028295.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez E, Kulkarni H, Bolivar H; et al. (2005). "The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility". Science. 307 (5714): 1434–40. doi:10.1126/science.1101160. PMID 15637236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ryu OH, Choi SJ, Firatli E; et al. (2005). "Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases". J. Biol. Chem. 280 (17): 17415–21. doi:10.1074/jbc.M500340200. PMID 15728180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burns JC, Shimizu C, Gonzalez E; et al. (2005). "Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease". J. Infect. Dis. 192 (2): 344–9. doi:10.1086/430953. PMID 15962231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)