CCNG2

Cyclin G2
Identifiers
Symbols	CCNG2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3208
Gene ontology Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin G2, also known as CCNG2, is a human gene.

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.

Further reading

• Horne MC, Goolsby GL, Donaldson KL; et al. (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. PMID 8626390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bates S, Rowan S, Vousden KH (1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.CS1 maint: Multiple names: authors list (link)
• Bennin DA, Don AS, Brake T; et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian YL, Liu FR, Liu J; et al. (2003). "[Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line]". Ai Zheng. 21 (6): 577–81. PMID 12452053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergqvist M, Brattström D, Brodin D; et al. (2006). "Genes associated with telomerase activity levels in esophageal carcinoma cell lines". Dis. Esophagus. 19 (1): 20–3. doi:10.1111/j.1442-2050.2006.00532.x. PMID 16364039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stossi F, Likhite VS, Katzenellenbogen JA, Katzenellenbogen BS (2006). "Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter". J. Biol. Chem. 281 (24): 16272–8. doi:10.1074/jbc.M513405200. PMID 16608856.CS1 maint: Multiple names: authors list (link)
• Arachchige Don AS, Dallapiazza RF, Bennin DA; et al. (2007). "Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest". Exp. Cell Res. 312 (20): 4181–204. doi:10.1016/j.yexcr.2006.09.023. PMID 17123511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)