CD200R1
| CD200 receptor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CD200R1 ; HCRTR2; OX2R; CD200R; MOX2R | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10957 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
CD200 receptor 1, also known as CD200R1, is a human gene.[1]
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[1]
References
Further reading
- Matsue H (2006). "CD 200-mediated regulation of skin immunity". J. Invest. Dermatol. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
- Shiratori I, Yamaguchi M, Suzukawa M; et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". J. Immunol. 175 (7): 4441–9. PMID 16177086.
- Cherwinski HM, Murphy CA, Joyce BL; et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". J. Immunol. 174 (3): 1348–56. PMID 15661892.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
- Foster-Cuevas M, Wright GJ, Puklavec MJ; et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". J. Virol. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMID 15220441.
- Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. PMID 15070969.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Wright GJ, Cherwinski H, Foster-Cuevas M; et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". J. Immunol. 171 (6): 3034–46. PMID 12960329.
- Vieites JM, de la Torre R, Ortega MA; et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. PMID 12853143.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Dick AD, Broderick C, Forrester JV, Wright GJ (2001). "Distribution of OX2 antigen and OX2 receptor within retina". Invest. Ophthalmol. Vis. Sci. 42 (1): 170–6. PMID 11133863.
- Wright GJ, Puklavec MJ, Willis AC; et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. PMID 10981966.
External links
- CD200R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.