CDC27
| Cell division cycle 27 homolog (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CDC27 ; APC3; CDC27Hs; D0S1430E; D17S978E; HNUC | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 960 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Cell division cycle 27 homolog (S. cerevisiae), also known as CDC27, is a human gene.[1]
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.[1]
References
Further reading
- Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (1995). "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition". Cell. 81 (2): 261–8. PMID 7736578.
- Chen PL, Ueng YC, Durfee T; et al. (1995). "Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner". Cell Growth Differ. 6 (2): 199–210. PMID 7756179.
- Tugendreich S, Boguski MS, Seldin MS, Hieter P (1993). "Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10031–5. PMID 8234252.
- Ho PP, Couch FJ, Brody LC; et al. (1996). "Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3". Somat. Cell Mol. Genet. 21 (5): 351–5. PMID 8619132.
- Ollendorff V, Donoghue DJ (1998). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". J. Biol. Chem. 272 (51): 32011–8. PMID 9405394.
- Yu H, Peters JM, King RW; et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. PMID 9469815.
- Shen M, Stukenberg PT, Kirschner MW, Lu KP (1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5): 706–20. PMID 9499405.
- Zhou BB, Li H, Yuan J, Kirschner MW (1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. PMID 9618490.
- Wassmann K, Benezra R (1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11193–8. PMID 9736712.
- Lu PJ, Zhou XZ, Shen M, Lu KP (1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. 283 (5406): 1325–8. PMID 10037602.
- Grossberger R, Gieffers C, Zachariae W; et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. PMID 10318877.
- Chan GK, Jablonski SA, Sudakin V; et al. (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". J. Cell Biol. 146 (5): 941–54. PMID 10477750.
- Gieffers C, Peters BH, Kramer ER; et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. PMID 10500174.
- Gmachl M, Gieffers C, Podtelejnikov AV; et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. PMID 10922056.
- Rippmann JF, Hobbie S, Daiber C; et al. (2000). "Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis". Cell Growth Differ. 11 (7): 409–16. PMID 10939594.
- Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Wendt KS, Vodermaier HC, Jacob U; et al. (2001). "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex". Nat. Struct. Biol. 8 (9): 784–8. doi:10.1038/nsb0901-784. PMID 11524682.
- Stroschein SL, Bonni S, Wrana JL, Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21): 2822–36. doi:10.1101/gad.912901. PMID 11691834.
- Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMID 12196507.
- Topper LM, Campbell MS, Tugendreich S; et al. (2002). "The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis". Cell Cycle. 1 (4): 282–92. PMID 12429948.
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