CDH15

Cadherin 15, M-cadherin (myotubule)
Identifiers
Symbols	CDH15 ; MCAD; CDH3; CDH14; CDHM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3622
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cadherin 15, M-cadherin (myotubule), also known as CDH15, is a human gene.

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.

Further reading

• Kaupmann K, Becker-Follmann J, Scherer G; et al. (1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. PMID 1427864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A (1991). "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8024–8. PMID 1840697.CS1 maint: Multiple names: authors list (link)
• Bornemann A, Schmalbruch H (1994). "Immunocytochemistry of M-cadherin in mature and regenerating rat muscle". Anat. Rec. 239 (2): 119–25. doi:10.1002/ar.1092390202. PMID 8059975.
• Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). "Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning". J. Biol. Chem. 272 (8): 5236–40. PMID 9030594.CS1 maint: Multiple names: authors list (link)
• Kuch C, Winnekendonk D, Butz S; et al. (1997). "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells". Exp. Cell Res. 232 (2): 331–8. doi:10.1006/excr.1997.3519. PMID 9168809.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimoyama Y, Shibata T, Kitajima M, Hirohashi S (1998). "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin". J. Biol. Chem. 273 (16): 10011–8. PMID 9545347.CS1 maint: Multiple names: authors list (link)
• Kremmidiotis G, Baker E, Crawford J; et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. PMID 10861224.CS1 maint: Multiple names: authors list (link)
• Kaufmann U, Zuppinger C, Waibler Z; et al. (2001). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell. Sci. 113 ( Pt 22): 4121–35. PMID 11058098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMID 11136230.CS1 maint: Multiple names: authors list (link)
• Hollnagel A, Grund C, Franke WW, Arnold HH (2002). "The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration". Mol. Cell. Biol. 22 (13): 4760–70. PMID 12052883.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang JS, Feinleib JL, Knox S; et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMID 12634428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)