CDK5R1

Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
File:PBB Protein CDK5R1 image.jpg PDB rendering based on 1h4l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1h4l​, 1ung​, 1unh​, 1unl​
Identifiers
Symbols	CDK5R1 ; CDK5P35; CDK5R; MGC33831; NCK5A; p23; p25; p35; p35nck5a
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31200
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin-dependent kinase 5, regulatory subunit 1 (p35), also known as CDK5R1, is a human gene.

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Further reading

• Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2: 91–6. doi:10.1080/13550280290167885. PMID 12491158.CS1 maint: Multiple names: authors list (link)
• Studzinski GP, Harrison JS (2003). "The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells". Leuk. Lymphoma. 44 (2): 235–40. PMID 12688339.
• Takahashi M, Tomizawa K, Sato K; et al. (1995). "A novel tau-tubulin kinase from bovine brain". FEBS Lett. 372 (1): 59–64. PMID 7556643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang D, Yeung J, Lee KY; et al. (1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". J. Biol. Chem. 270 (45): 26897–903. PMID 7592934.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai LH, Delalle I, Caviness VS; et al. (1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature. 371 (6496): 419–23. doi:10.1038/371419a0. PMID 8090221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chae T, Kwon YT, Bronson R; et al. (1997). "Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality". Neuron. 18 (1): 29–42. PMID 9010203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poon RY, Lew J, Hunter T (1997). "Identification of functional domains in the neuronal Cdk5 activator protein". J. Biol. Chem. 272 (9): 5703–8. PMID 9038181.CS1 maint: Multiple names: authors list (link)
• Fletcher AI, Shuang R, Giovannucci DR; et al. (1999). "Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18". J. Biol. Chem. 274 (7): 4027–35. PMID 9933594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patrick GN, Zukerberg L, Nikolic M; et al. (2000). "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration". Nature. 402 (6762): 615–22. doi:10.1038/45159. PMID 10604467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ching YP, Qi Z, Wang JH (2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. PMID 10721722.CS1 maint: Multiple names: authors list (link)
• Kwon YT, Gupta A, Zhou Y; et al. (2000). "Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase". Curr. Biol. 10 (7): 363–72. PMID 10753743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee MS, Kwon YT, Li M; et al. (2000). "Neurotoxicity induces cleavage of p35 to p25 by calpain". Nature. 405 (6784): 360–4. doi:10.1038/35012636. PMID 10830966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang X, Ching YP, Lam WH; et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Floyd SR, Porro EB, Slepnev VI; et al. (2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kesavapany S, Lau KF, McLoughlin DM; et al. (2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction". Eur. J. Neurosci. 13 (2): 241–7. PMID 11168528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen F, Studzinski GP (2001). "Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation". Blood. 97 (12): 3763–7. PMID 11389014.
• Tarricone C, Dhavan R, Peng J; et al. (2001). "Structure and regulation of the CDK5-p25(nck5a) complex". Mol. Cell. 8 (3): 657–69. PMID 11583627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rashid T, Banerjee M, Nikolic M (2002). "Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology". J. Biol. Chem. 276 (52): 49043–52. doi:10.1074/jbc.M105599200. PMID 11604394.CS1 maint: Multiple names: authors list (link)
• Qu D, Li Q, Lim HY; et al. (2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patzke H, Tsai LH (2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29". J. Biol. Chem. 277 (10): 8054–60. doi:10.1074/jbc.M109645200. PMID 11784720.