CDKN3

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
PDB rendering based on 1fpz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fpz​, 1fq1​
Identifiers
Symbols	CDKN3 ; CDI1; CIP2; FLJ25787; KAP; KAP1; MGC70625
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3805
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase), also known as CDKN3, is a human gene.

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.

Further reading

• Poon RY, Hunter T (1995). "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin". Science. 270 (5233): 90–3. PMID 7569954.
• Demetrick DJ, Matsumoto S, Hannon GJ; et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. PMID 7698009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hannon GJ, Casso D, Beach D (1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1731–5. PMID 8127873.CS1 maint: Multiple names: authors list (link)
• Gyuris J, Golemis E, Chertkov H, Brent R (1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. PMID 8242750.CS1 maint: Multiple names: authors list (link)
• Harper JW, Adami GR, Wei N; et al. (1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. PMID 8242751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sexl V, Diehl JA, Sherr CJ; et al. (1999). "A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2". Oncogene. 18 (3): 573–82. doi:10.1038/sj.onc.1202362. PMID 9989807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SW, Reimer CL, Fang L; et al. (2000). "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression". Mol. Cell. Biol. 20 (5): 1723–32. PMID 10669749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yeh CT, Lu SC, Chen TC; et al. (2000). "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma". Cancer Res. 60 (17): 4697–700. PMID 10987270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song H, Hanlon N, Brown NR; et al. (2001). "Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2". Mol. Cell. 7 (3): 615–26. PMID 11463386.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang H, Iakova P, Wilde M; et al. (2001). "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4". Mol. Cell. 8 (4): 817–28. PMID 11684017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donato JL, Ko J, Kutok JL; et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. PMID 11781350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yeh CT, Lu SC, Chao CH, Chao ML (2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2): 311–4. PMID 12745075.CS1 maint: Multiple names: authors list (link)
• Niculescu MD, Yamamuro Y, Zeisel SH (2004). "Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene". J. Neurochem. 89 (5): 1252–9. doi:10.1111/j.1471-4159.2004.02414.x. PMID 15147518.CS1 maint: Multiple names: authors list (link)
• Chinami M, Yano Y, Yang X; et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2". J. Biol. Chem. 280 (17): 17235–42. doi:10.1074/jbc.M413437200. PMID 15671017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsieh MJ, Yao YL, Lai IL, Yang WM (2006). "Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1". Biochem. Biophys. Res. Commun. 349 (2): 573–81. doi:10.1016/j.bbrc.2006.08.064. PMID 16945326.CS1 maint: Multiple names: authors list (link)
• Okamoto K, Kitabayashi I, Taya Y (2006). "KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction". Biochem. Biophys. Res. Commun. 351 (1): 216–22. doi:10.1016/j.bbrc.2006.10.022. PMID 17056014.CS1 maint: Multiple names: authors list (link)