CHAF1B

Chromatin assembly factor 1, subunit B (p60)
Identifiers
Symbols	CHAF1B ; CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48346
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromatin assembly factor 1, subunit B (p60), also known as CHAF1B, is a human gene.

Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.

Further reading

• Ridgway P, Almouzni G (2000). "CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair". J. Cell. Sci. 113 ( Pt 15): 2647–58. PMID 10893180.
• Kaufman PD, Kobayashi R, Kessler N, Stillman B (1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. PMID 7600578.CS1 maint: Multiple names: authors list (link)
• Blouin JL, Duriaux-Sail G, Chen H; et al. (1997). "Mapping of the gene for the p60 subunit of the human chromatin assembly factor (CAF1A) to the Down syndrome region of chromosome 21". Genomics. 33 (2): 309–12. doi:10.1006/geno.1996.0199. PMID 8660983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katsanis N, Fisher EM (1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Hum. Genet. 98 (4): 497–9. PMID 8792829.
• Verreault A, Kaufman PD, Kobayashi R, Stillman B (1996). "Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4". Cell. 87 (1): 95–104. PMID 8858152.CS1 maint: Multiple names: authors list (link)
• Matsumoto-Taniura N, Pirollet F, Monroe R; et al. (1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol. Biol. Cell. 7 (9): 1455–69. PMID 8885239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marheineke K, Krude T (1998). "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle". J. Biol. Chem. 273 (24): 15279–86. PMID 9614144.
• Martini E, Roche DM, Marheineke K; et al. (1998). "Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells". J. Cell Biol. 143 (3): 563–75. PMID 9813080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Keller C, Krude T (2001). "Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis". J. Biol. Chem. 275 (45): 35512–21. doi:10.1074/jbc.M003073200. PMID 10938080.
• Mello JA, Silljé HH, Roche DM; et al. (2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMID 11897662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morel AP, Sentis S, Bianchin C; et al. (2004). "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. Cell. Sci. 116 (Pt 14): 2929–36. doi:10.1242/jcs.00480. PMID 12771185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nabatiyan A, Krude T (2004). "Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis". Mol. Cell. Biol. 24 (7): 2853–62. PMID 15024074.
• Shim KS, Bergelson JM, Furuse M; et al. (2004). "Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain". J. Neural Transm. Suppl. (67): 117–28. PMID 15068244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMID 15456888.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groth A, Ray-Gallet D, Quivy JP; et al. (2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Mol. Cell. 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)