CHD1

Chromodomain helicase DNA binding protein 1
PDB rendering based on 2b2t.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2b2t​, 2b2u​, 2b2v​, 2b2w​, 2b2y​
Identifiers
Symbols	CHD1 ; DKFZp686E2337
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86052
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromodomain helicase DNA binding protein 1, also known as CHD1, is a human gene.

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.

Further reading

• Stokes DG, Perry RP (1995). "DNA-binding and chromatin localization properties of CHD1". Mol. Cell. Biol. 15 (5): 2745–53. PMID 7739555.
• Delmas V, Stokes DG, Perry RP (1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2414–8. PMID 8460153.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Woodage T, Basrai MA, Baxevanis AD; et al. (1997). "Characterization of the CHD family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472–7. PMID 9326634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kelley DE, Stokes DG, Perry RP (1999). "CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin". Chromosoma. 108 (1): 10–25. PMID 10199952.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salomon AR, Ficarro SB, Brill LM; et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tai HH, Geisterfer M, Bell JC; et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. PMID 12890497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sims RJ, Chen CF, Santos-Rosa H; et al. (2006). "Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains". J. Biol. Chem. 280 (51): 41789–92. doi:10.1074/jbc.C500395200. PMID 16263726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flanagan JF, Mi LZ, Chruszcz M; et al. (2006). "Double chromodomains cooperate to recognize the methylated histone H3 tail". Nature. 438 (7071): 1181–5. doi:10.1038/nature04290. PMID 16372014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okuda M, Horikoshi M, Nishimura Y (2007). "Structural polymorphism of chromodomains in Chd1". J. Mol. Biol. 365 (4): 1047–62. doi:10.1016/j.jmb.2006.10.039. PMID 17098252.CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)