CHD3

Chromodomain helicase DNA binding protein 3
Identifiers
Symbols	CHD3 ; Mi-2a; Mi2-ALPHA; ZFH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 62693
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromodomain helicase DNA binding protein 3, also known as CHD3, is a human gene.

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Further reading

• Bowen NJ, Fujita N, Kajita M, Wade PA (2004). "Mi-2/NuRD: multiple complexes for many purposes". Biochim. Biophys. Acta. 1677 (1–3): 52–7. doi:10.1016/j.bbaexp.2003.10.010. PMID 15020045.CS1 maint: Multiple names: authors list (link)
• Gieser L, Swaroop A (1992). "Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library". Genomics. 13 (3): 873–6. PMID 1639417.
• Ge Q, Nilasena DS, O'Brien CA; et al. (1995). "Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen". J. Clin. Invest. 96 (4): 1730–7. PMID 7560064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seelig HP, Moosbrugger I, Ehrfeld H; et al. (1995). "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation". Arthritis Rheum. 38 (10): 1389–99. PMID 7575689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seelig HP, Renz M, Targoff IN; et al. (1996). "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen". Arthritis Rheum. 39 (10): 1769–71. PMID 8843877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Woodage T, Basrai MA, Baxevanis AD; et al. (1997). "Characterization of the CHD family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472–7. PMID 9326634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aubry F, Mattéi MG, Galibert F (1998). "Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family". Eur. J. Biochem. 254 (3): 558–64. PMID 9688266.CS1 maint: Multiple names: authors list (link)
• Tong JK, Hassig CA, Schnitzler GR; et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleiderlein JJ, Nisson PE, Jessee J; et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. PMID 9921901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim J, Sif S, Jones B; et al. (1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity. 10 (3): 345–55. PMID 10204490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wade PA, Gegonne A, Jones PL; et al. (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nat. Genet. 23 (1): 62–6. doi:10.1038/12664. PMID 10471500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.CS1 maint: Multiple names: authors list (link)
• Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.CS1 maint: Multiple names: authors list (link)
• Schultz DC, Friedman JR, Rauscher FJ (2001). "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD". Genes Dev. 15 (4): 428–43. doi:10.1101/gad.869501. PMID 11230151.CS1 maint: Multiple names: authors list (link)
• Yasui D, Miyano M, Cai S; et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemos TA, Passos DO, Nery FC, Kobarg J (2003). "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Lett. 533 (1–3): 14–20. PMID 12505151.CS1 maint: Multiple names: authors list (link)
• Fujita N, Jaye DL, Kajita M; et al. (2003). "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell. 113 (2): 207–19. PMID 12705869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee BH, Yoshimatsu K, Maeda A; et al. (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. PMID 14609633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)