CHFR

Checkpoint with forkhead and ring finger domains
PDB rendering based on 1lgp.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1lgp​, 1lgq​
Identifiers
Symbols	CHFR ; FLJ10796; FLJ33629; RNF116; RNF196
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10078
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Checkpoint with forkhead and ring finger domains, also known as CHFR, is a human gene.

Further reading

• Scolnick DM, Halazonetis TD (2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature. 406 (6794): 430–5. doi:10.1038/35019108. PMID 10935642.
• Kang D, Chen J, Wong J, Fang G (2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J. Cell Biol. 156 (2): 249–59. doi:10.1083/jcb.200108016. PMID 11807090.CS1 maint: Multiple names: authors list (link)
• Chaturvedi P, Sudakin V, Bobiak ML; et al. (2002). "Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity". Cancer Res. 62 (6): 1797–801. PMID 11912157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizuno K, Osada H, Konishi H; et al. (2002). "Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers". Oncogene. 21 (15): 2328–33. doi:10.1038/sj.onc.1205402. PMID 11948416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stavridi ES, Huyen Y, Loreto IR; et al. (2002). "Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate". Structure. 10 (7): 891–9. PMID 12121644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibata Y, Haruki N, Kuwabara Y; et al. (2002). "Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer". Carcinogenesis. 23 (10): 1695–9. PMID 12376479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corn PG, Summers MK, Fogt F; et al. (2003). "Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer". Carcinogenesis. 24 (1): 47–51. PMID 12538348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toyota M, Sasaki Y, Satoh A; et al. (2003). "Epigenetic inactivation of CHFR in human tumors". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7818–23. doi:10.1073/pnas.1337066100. PMID 12810945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bothos J, Summers MK, Venere M; et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains". Oncogene. 22 (46): 7101–7. doi:10.1038/sj.onc.1206831. PMID 14562038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mariatos G, Bothos J, Zacharatos P; et al. (2004). "Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer". Cancer Res. 63 (21): 7185–9. PMID 14612512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shtivelman E (2004). "Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR". Mol. Cancer Res. 1 (13): 959–69. PMID 14638868.
• Bertholon J, Wang Q, Falette N; et al. (2004). "Chfr inactivation is not associated to chromosomal instability in colon cancers". Oncogene. 22 (55): 8956–60. doi:10.1038/sj.onc.1207078. PMID 14654793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Erson AE, Petty EM (2004). "CHFR-associated early G2/M checkpoint defects in breast cancer cells". Mol. Carcinog. 39 (1): 26–33. doi:10.1002/mc.10161. PMID 14694445.
• Satoh A, Toyota M, Itoh F; et al. (2004). "Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer". Cancer Res. 63 (24): 8606–13. PMID 14695171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang HC, Kim IJ, Park JH; et al. (2005). "Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncol. Rep. 12 (1): 129–33. PMID 15201973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsusaka T, Pines J (2004). "Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells". J. Cell Biol. 166 (4): 507–16. doi:10.1083/jcb.200401139. PMID 15302856.
• Daniels MJ, Marson A, Venkitaraman AR (2004). "PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein". Nat. Struct. Mol. Biol. 11 (11): 1114–21. doi:10.1038/nsmb837. PMID 15467728.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)