CHI3L1

Chitinase 3-like 1 (cartilage glycoprotein-39)
PDB rendering based on 1hjv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hjv​, 1hjw​, 1hjx​, 1nwr​, 1nws​, 1nwt​, 1nwu​
Identifiers
Symbols	CHI3L1 ; GP39; HC-gp39; HCGP-3P; YKL40; YYL-40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55569
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chitinase 3-like 1 (cartilage glycoprotein-39), also known as CHI3L1, is a human gene. It has been implicated in asthma, with the discovery of an allele that doubles the risk.

Further reading

• Rathcke CN, Vestergaard H (2007). "YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis". Inflamm. Res. 55 (6): 221–7. doi:10.1007/s00011-006-0076-y. PMID 16955240.
• Nyirkos P, Golds EE (1990). "Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period". Biochem. J. 269 (1): 265–8. PMID 2375755.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Hakala BE, White C, Recklies AD (1994). "Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family". J. Biol. Chem. 268 (34): 25803–10. PMID 8245017.CS1 maint: Multiple names: authors list (link)
• Rehli M, Krause SW, Andreesen R (1997). "Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation". Genomics. 43 (2): 221–5. doi:10.1006/geno.1997.4778. PMID 9244440.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kirkpatrick RB, Emery JG, Connor JR; et al. (1998). "Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages". Exp. Cell Res. 237 (1): 46–54. doi:10.1006/excr.1997.3764. PMID 9417865.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Renkema GH, Boot RG, Au FL; et al. (1998). "Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages". Eur. J. Biochem. 251 (1–2): 504–9. PMID 9492324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johansen JS, Stoltenberg M, Hansen M; et al. (1999). "Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity". Rheumatology (Oxford). 38 (7): 618–26. PMID 10461474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nordenbaek C, Johansen JS, Junker P; et al. (1999). "YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization". J. Infect. Dis. 180 (5): 1722–6. PMID 10515841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Connor JR, Dodds RA, Emery JG; et al. (2000). "Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization". Osteoarthr. Cartil. 8 (2): 87–95. doi:10.1053/joca.1999.0276. PMID 10772238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Østergaard C, Johansen JS, Benfield T; et al. (2002). "YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis". Clin. Diagn. Lab. Immunol. 9 (3): 598–604. PMID 11986266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kronborg G, Ostergaard C, Weis N; et al. (2003). "Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease". Scand. J. Infect. Dis. 34 (5): 323–6. PMID 12069012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Recklies AD, White C, Ling H (2002). "The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways". Biochem. J. 365 (Pt 1): 119–26. doi:10.1042/BJ20020075. PMID 12071845.CS1 maint: Multiple names: authors list (link)
• Cintin C, Johansen JS, Christensen IJ; et al. (2002). "High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival". Cancer. 95 (2): 267–74. doi:10.1002/cncr.10644. PMID 12124825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steck E, Breit S, Breusch SJ; et al. (2003). "Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage". Biochem. Biophys. Res. Commun. 299 (1): 109–15. PMID 12435396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steenbakkers PG, Baeten D, Rovers E; et al. (2003). "Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies". J. Immunol. 170 (11): 5719–27. PMID 12759455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Houston DR, Recklies AD, Krupa JC, van Aalten DM (2003). "Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes". J. Biol. Chem. 278 (32): 30206–12. doi:10.1074/jbc.M303371200. PMID 12775711.CS1 maint: Multiple names: authors list (link)
• Nishikawa KC, Millis AJ (2003). "gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells". Exp. Cell Res. 287 (1): 79–87. PMID 12799184.