CLDN2

Claudin 2
Identifiers
Symbols	CLDN2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9621
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Claudin 2, also known as CLDN2, is a human gene.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM]

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. PMID 11247307.CS1 maint: Multiple names: authors list (link)
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.CS1 maint: Multiple names: authors list (link)
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. PMID 12475568.CS1 maint: Multiple names: authors list (link)
• Furuse M, Fujita K, Hiiragi T; et al. (1998). "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin". J. Cell Biol. 141 (7): 1539–50. PMID 9647647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. PMID 9892664.CS1 maint: Multiple names: authors list (link)
• Itoh M, Furuse M, Morita K; et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–63. PMID 10601346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakaguchi T, Gu X, Golden HM; et al. (2002). "Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha". J. Biol. Chem. 277 (24): 21361–70. doi:10.1074/jbc.M110261200. PMID 11934881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colegio OR, Van Itallie C, Rahner C, Anderson JM (2003). "Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture". Am. J. Physiol., Cell Physiol. 284 (6): C1346–54. doi:10.1152/ajpcell.00547.2002. PMID 12700140.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mankertz J, Hillenbrand B, Tavalali S; et al. (2004). "Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity". Biochem. Biophys. Res. Commun. 314 (4): 1001–7. PMID 14751232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamauchi K, Rai T, Kobayashi K; et al. (2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690–4. doi:10.1073/pnas.0306924101. PMID 15070779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Escaffit F, Boudreau F, Beaulieu JF (2005). "Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells". J. Cell. Physiol. 203 (1): 15–26. doi:10.1002/jcp.20189. PMID 15389642.CS1 maint: Multiple names: authors list (link)