CLK1

CDC-like kinase 1
PDB rendering based on 1z57.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1z57​
Identifiers
Symbols	CLK1 ; CLK; CLK/STY; STY
External IDs	Template:OMIM5 HomoloGene: 48263
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CDC-like kinase 1, also known as CLK1, is a human gene.

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.

Further reading

• Johnson KW, Smith KA (1991). "Molecular cloning of a novel human cdc2/CDC28-like protein kinase". J. Biol. Chem. 266 (6): 3402–7. PMID 1704889.
• Ben-David Y, Letwin K, Tannock L; et al. (1991). "A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators". EMBO J. 10 (2): 317–25. PMID 1825055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanes J, von der Kammer H, Klaudiny J, Scheit KH (1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J. Mol. Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.CS1 maint: Multiple names: authors list (link)
• Colwill K, Pawson T, Andrews B; et al. (1996). "The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution". EMBO J. 15 (2): 265–75. PMID 8617202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colwill K, Feng LL, Yeakley JM; et al. (1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. PMID 8798720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nestel FP, Colwill K, Harper S; et al. (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin". Gene. 180 (1–2): 151–5. PMID 8973360.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Talmadge CB, Finkernagel S, Sumegi J; et al. (1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum. Genet. 103 (4): 523–4. PMID 9856501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moeslein FM, Myers MP, Landreth GE (1999). "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B". J. Biol. Chem. 274 (38): 26697–704. PMID 10480872.CS1 maint: Multiple names: authors list (link)
• Menegay HJ, Myers MP, Moeslein FM, Landreth GE (2000). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell. Sci. 113 ( Pt 18): 3241–53. PMID 10954422.CS1 maint: Multiple names: authors list (link)
• Kojima T, Zama T, Wada K; et al. (2001). "Cloning of human PRP4 reveals interaction with Clk1". J. Biol. Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartmann AM, Rujescu D, Giannakouros T; et al. (2001). "Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors". Mol. Cell. Neurosci. 18 (1): 80–90. doi:10.1006/mcne.2001.1000. PMID 11461155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai MC, Lin RI, Tarn WY (2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". Biochem. J. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMID 12549978.CS1 maint: Multiple names: authors list (link)
• Umehara H, Nishii Y, Morishima M; et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. PMID 12565863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kantham L, Kerr-Bayles L, Godde N; et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. PMID 12705895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prasad J, Manley JL (2003). "Regulation and substrate specificity of the SR protein kinase Clk/Sty". Mol. Cell. Biol. 23 (12): 4139–49. PMID 12773558.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.CS1 maint: Multiple names: authors list (link)
• Muraki M, Ohkawara B, Hosoya T; et al. (2004). "Manipulation of alternative splicing by a newly developed inhibitor of Clks". J. Biol. Chem. 279 (23): 24246–54. doi:10.1074/jbc.M314298200. PMID 15010457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Velazquez-Dones A, Hagopian JC, Ma CT; et al. (2006). "Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty". J. Biol. Chem. 280 (50): 41761–8. doi:10.1074/jbc.M504156200. PMID 16223727.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)