CLK2
| CDC-like kinase 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CLK2 ; MGC61500; hCLK2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 33303 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
CDC-like kinase 2, also known as CLK2, is a human gene.[1]
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.[1]
References
Further reading
- Hanes J, von der Kammer H, Klaudiny J, Scheit KH (1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J. Mol. Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
- Lee K, Du C, Horn M, Rabinow L (1996). "Activity and autophosphorylation of LAMMER protein kinases". J. Biol. Chem. 271 (44): 27299–303. PMID 8910305.
- Winfield SL, Tayebi N, Martin BM; et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Res. 7 (10): 1020–6. PMID 9331372.
- Duncan PI, Stojdl DF, Marius RM; et al. (1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Exp. Cell Res. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.
- Tsujikawa M, Kurahashi H, Tanaka T; et al. (1998). "Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p". Am. J. Hum. Genet. 63 (4): 1073–7. PMID 9758629.
- Nayler O, Schnorrer F, Stamm S, Ullrich A (1999). "The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation". J. Biol. Chem. 273 (51): 34341–8. PMID 9852100.
- Talmadge CB, Finkernagel S, Sumegi J; et al. (1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum. Genet. 103 (4): 523–4. PMID 9856501.
- Moeslein FM, Myers MP, Landreth GE (1999). "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B". J. Biol. Chem. 274 (38): 26697–704. PMID 10480872.
- Nothwang HG, Kim HG, Aoki J; et al. (2001). "Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain". Hum. Mol. Genet. 10 (8): 797–806. PMID 11285245.
- Ravichandran LV, Chen H, Li Y, Quon MJ (2002). "Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor". Mol. Endocrinol. 15 (10): 1768–80. PMID 11579209.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jiang N, Bénard CY, Kébir H; et al. (2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J. Biol. Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Collis SJ, Barber LJ, Clark AJ; et al. (2007). "HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability". Nat. Cell Biol. 9 (4): 391–401. doi:10.1038/ncb1555. PMID 17384638.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |