CLSPN

Claspin homolog (Xenopus laevis)
Identifiers
Symbols	CLSPN ; CLASPIN; MGC131612; MGC131613; MGC131615
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11138
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Claspin homolog (Xenopus laevis), also known as CLSPN, is a human gene.

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.

Further reading

• Chini CC, Chen J (2005). "Claspin, a regulator of Chk1 in DNA replication stress pathway". DNA Repair (Amst.). 3 (8–9): 1033–7. doi:10.1016/j.dnarep.2004.03.001. PMID 15279790.
• Kumagai A, Dunphy WG (2000). "Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts". Mol. Cell. 6 (4): 839–49. PMID 11090622.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chini CC, Chen J (2003). "Human claspin is required for replication checkpoint control". J. Biol. Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
• Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484–9. doi:10.1073/pnas.0401847101. PMID 15096610.CS1 maint: Multiple names: authors list (link)
• Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2006). "ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage". Cell Cycle. 3 (7): 941–5. PMID 15190204.CS1 maint: Multiple names: authors list (link)
• Sar F, Lindsey-Boltz LA, Subramanian D; et al. (2004). "Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures". J. Biol. Chem. 279 (38): 39289–95. doi:10.1074/jbc.M405793200. PMID 15226314.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clarke CA, Clarke PR (2005). "DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system". Biochem. J. 388 (Pt 2): 705–12. doi:10.1042/BJ20041966. PMID 15707391.
• Clarke CA, Bennett LN, Clarke PR (2005). "Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway". J. Biol. Chem. 280 (42): 35337–45. doi:10.1074/jbc.M506460200. PMID 16123041.CS1 maint: Multiple names: authors list (link)
• Chini CC, Wood J, Chen J (2006). "Chk1 is required to maintain claspin stability". Oncogene. 25 (30): 4165–71. doi:10.1038/sj.onc.1209447. PMID 16501606.CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennett LN, Clarke PR (2006). "Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation". FEBS Lett. 580 (17): 4176–81. doi:10.1016/j.febslet.2006.06.071. PMID 16828751.
• Liu S, Bekker-Jensen S, Mailand N; et al. (2006). "Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation". Mol. Cell. Biol. 26 (16): 6056–64. doi:10.1128/MCB.00492-06. PMID 16880517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mailand N, Bekker-Jensen S, Bartek J, Lukas J (2006). "Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress". Mol. Cell. 23 (3): 307–18. doi:10.1016/j.molcel.2006.06.016. PMID 16885021.CS1 maint: Multiple names: authors list (link)
• Peschiaroli A, Dorrello NV, Guardavaccaro D; et al. (2006). "SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response". Mol. Cell. 23 (3): 319–29. doi:10.1016/j.molcel.2006.06.013. PMID 16885022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mamely I, van Vugt MA, Smits VA; et al. (2006). "Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery". Curr. Biol. 16 (19): 1950–5. doi:10.1016/j.cub.2006.08.026. PMID 16934469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R; et al. (2007). "Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells". Cancer Res. 66 (17): 8672–9. doi:10.1158/0008-5472.CAN-05-4443. PMID 16951182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chini CC, Chen J (2006). "Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function". J. Biol. Chem. 281 (44): 33276–82. doi:10.1074/jbc.M604373200. PMID 16963448.