CNDP1

Carnosine dipeptidase 1 (metallopeptidase M20 family)
Identifiers
Symbols	CNDP1 ; CN1; CPGL2; HsT2308; MGC102737; MGC10825; MGC142072
External IDs	Template:MGI HomoloGene: 57178
Gene ontology
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Carnosine dipeptidase 1 (metallopeptidase M20 family), also known as CNDP1, is a human gene.

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.

The metabolic disorder Carnosinemia may be caused by mutations in this gene.

Further reading

• Lenney JF, Peppers SC, Kucera CM, Sjaastad O (1983). "Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine". Clin. Chim. Acta. 132 (2): 157–65. PMID 6616870.CS1 maint: Multiple names: authors list (link)
• Lenney JF, George RP, Weiss AM; et al. (1982). "Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium". Clin. Chim. Acta. 123 (3): 221–31. PMID 7116644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Teufel M, Saudek V, Ledig JP; et al. (2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". J. Biol. Chem. 278 (8): 6521–31. doi:10.1074/jbc.M209764200. PMID 12473676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ghose S, Weickert CS, Colvin SM; et al. (2004). "Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia". Neuropsychopharmacology. 29 (1): 117–25. doi:10.1038/sj.npp.1300304. PMID 14560319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janssen B, Hohenadel D, Brinkkoetter P; et al. (2005). "Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1". Diabetes. 54 (8): 2320–7. PMID 16046297.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zschocke J, Nebel A, Wicks K; et al. (2007). "Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease". Mech. Ageing Dev. 127 (11): 817–20. doi:10.1016/j.mad.2006.08.002. PMID 16965804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang P, Chan DW, Zhu Y; et al. (2007). "Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma". Clin. Cancer Res. 12 (22): 6617–25. doi:10.1158/1078-0432.CCR-06-1307. PMID 17121880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Freedman BI, Hicks PJ, Sale MM; et al. (2007). "A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans". Nephrol. Dial. Transplant. 22 (4): 1131–5. doi:10.1093/ndt/gfl717. PMID 17205963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riedl E, Koeppel H, Brinkkoetter P; et al. (2007). "A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells". Diabetes. 56 (9): 2410–3. doi:10.2337/db07-0128. PMID 17601991.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sauerhöfer S, Yuan G, Braun GS; et al. (2007). "L-carnosine, a substrate of carnosinase-1, influences glucose metabolism". Diabetes. 56 (10): 2425–32. doi:10.2337/db07-0177. PMID 17601992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)