COP9 constitutive photomorphogenic homolog subunit 5

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Identifiers
Symbols	COPS5 ; CSN5; JAB1; MGC3149; MOV-34; SGN5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55992
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5, is a human gene.

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.

Further reading

• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.CS1 maint: Multiple names: authors list (link)
• Claret FX, Hibi M, Dhut S; et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asano K, Vornlocher HP, Richter-Cook NJ; et al. (1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. PMID 9341143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seeger M, Kraft R, Ferrell K; et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei N, Tsuge T, Serino G; et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. PMID 9707402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomoda K, Kubota Y, Kato J (1999). "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1". Nature. 398 (6723): 160–5. doi:10.1038/18230. PMID 10086358.CS1 maint: Multiple names: authors list (link)
• Dechend R, Hirano F, Lehmann K; et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chauchereau A, Georgiakaki M, Perrin-Wolff M; et al. (2000). "JAB1 interacts with both the progesterone receptor and SRC-1". J. Biol. Chem. 275 (12): 8540–8. PMID 10722692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bianchi E, Denti S, Granata A; et al. (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity". Nature. 404 (6778): 617–21. doi:10.1038/35007098. PMID 10766246.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleemann R, Hausser A, Geiger G; et al. (2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. doi:10.1038/35041591. PMID 11089976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bech-Otschir D, Kraft R, Huang X; et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMID 11285227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lyapina S, Cope G, Shevchenko A; et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomoda K, Kubota Y, Arata Y; et al. (2002). "The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex". J. Biol. Chem. 277 (3): 2302–10. doi:10.1074/jbc. M104431200 . PMID 11704659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bae MK, Ahn MY, Jeong JW; et al. (2002). "Jab1 interacts directly with HIF-1alpha and regulates its stability". J. Biol. Chem. 277 (1): 9–12. doi:10.1074/jbc. C100442200 . PMID 11707426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu C, Li Y, Zhao Y; et al. (2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB J. 16 (1): 90–2. doi:10.1096/fj.01-0506fje. PMID 11709497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". J. Biol. Chem. 277 (15): 12604–12. doi:10.1074/jbc. M200283200 . PMID 11812799.
• Wan M, Cao X, Wu Y; et al. (2002). "Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation". EMBO Rep. 3 (2): 171–6. doi:10.1093/embo-reports/kvf024. PMID 11818334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gemmill RM, Bemis LT, Lee JP; et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caballero OL, Resto V, Patturajan M; et al. (2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ (2002). "Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1". J. Biol. Chem. 277 (36): 32413–6. doi:10.1074/jbc. C200311200 . PMID 12119282.CS1 maint: Multiple names: authors list (link)