COPS8

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
Identifiers
Symbols	COPS8 ; COP9; CSN8; MGC1297; MGC43256; SGN8
External IDs	Template:MGI HomoloGene: 4882
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis), also known as COPS8, is a human gene.

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

• Schwechheimer C, Deng XW (2001). "COP9 signalosome revisited: a novel mediator of protein degradation". Trends Cell Biol. 11 (10): 420–6. PMID 11567875.
• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.CS1 maint: Multiple names: authors list (link)
• Chamovitz DA, Deng XW (1995). "The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms". Cell. 82 (3): 353–4. PMID 7634324.
• Chamovitz DA, Wei N, Osterlund MT; et al. (1996). "The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch". Cell. 86 (1): 115–21. PMID 8689678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seeger M, Kraft R, Ferrell K; et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei N, Tsuge T, Serino G; et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. PMID 9707402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naumann M, Bech-Otschir D, Huang X; et al. (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK". J. Biol. Chem. 274 (50): 35297–300. PMID 10585392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen H, Azriel A, Cohen T; et al. (2001). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi:10.1074/jbc.M004900200. PMID 10991940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gizatullin RZ, Muravenko OV, Al-Amin AN; et al. (2001). "Human COP9 subunit 8 homolog gene SGN8 Map position 2q37". Chromosome Res. 8 (6): 559. PMID 11032325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bech-Otschir D, Kraft R, Huang X; et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMID 11285227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lyapina S, Cope G, Shevchenko A; et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. PMID 12220626.CS1 maint: Multiple names: authors list (link)
• Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi:10.1074/jbc.M208709200. PMID 12324474.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Serino G, Su H, Peng Z; et al. (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex". Plant Cell. 15 (3): 719–31. PMID 12615944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhle S, Medalia O, Waldron R; et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMID 12628923.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groisman R, Polanowska J, Kuraoka I; et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. PMID 12732143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)