COTL1

Coactosin-like 1 (Dictyostelium)
PDB rendering based on 1t2l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1t2l​, 1t3x​, 1t3y​, 1tmw​, 1udm​, 1vfq​, 1wm4​, 1wnj​
Identifiers
Symbols	COTL1 ; CLP; FLJ43657; MGC19733
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10898
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Coactosin-like 1 (Dictyostelium), also known as COTL1, is a human gene.

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Further reading

• Wu C, Friedlander P, Lamoureux C; et al. (1993). "cDNA clones contain autonomous replication activity". Biochim. Biophys. Acta. 1174 (3): 241–57. PMID 7690594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen KS, Manian P, Koeuth T; et al. (1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Provost P, Samuelsson B, Rådmark O (1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. PMID 10051563.CS1 maint: Multiple names: authors list (link)
• Provost P, Doucet J, Hammarberg T; et al. (2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Provost P, Doucet J, Stock A; et al. (2001). "Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75". Biochem. J. 359 (Pt 2): 255–63. PMID 11583571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakatsura T, Senju S, Ito M; et al. (2002). "Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method". Eur. J. Immunol. 32 (3): 826–36. PMID 11870627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai H, Wu J, Xu Y; et al. (2005). "1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N". J. Biomol. NMR. 29 (3): 455–6. doi:10.1023/B:JNMR.0000032550.18424.aa. PMID 15213466.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu L, Wang Y, Zhang P; et al. (2005). "Expression, purification and preliminary crystallographic studies of human coactosin-like protein". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 9): 1651–3. doi:10.1107/S0907444904016701. PMID 15333945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Liu X, Lou Z; et al. (2005). "Crystal structure of human coactosin-like protein at 1.9 A resolution". Protein Sci. 13 (11): 2845–51. doi:10.1110/ps.04937304. PMID 15459340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Liu X, Zhao Q; et al. (2005). "Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP)". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 12 Pt 2): 2387–8. doi:10.1107/S0907444904028112. PMID 15583396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Staes A, Van Damme J; et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rakonjac M, Fischer L, Provost P; et al. (2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMID 16924104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai H, Huang W, Xu J; et al. (2006). "Binding model of human coactosin-like protein with filament actin revealed by mutagenesis". Biochim. Biophys. Acta. 1764 (11): 1688–700. doi:10.1016/j.bbapap.2006.06.017. PMID 17070122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)