CPD (gene)
Carboxypeptidase D | |||||||||||
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Identifiers | |||||||||||
Symbols | CPD ; | ||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 999 | ||||||||||
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RNA expression pattern | |||||||||||
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Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
Carboxypeptidase D, also known as CPD, is a human gene.[1]
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[1]
References
Further reading
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- McGwire GB, Tan F, Michel B; et al. (1997). "Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein". Life Sci. 60 (10): 715–24. PMID 9064476.
- Tan F, Rehli M, Krause SW, Skidgel RA (1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". Biochem. J. 327 ( Pt 1): 81–7. PMID 9355738.
- Varlamov O, Fricker LD (1998). "Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface". J. Cell. Sci. 111 ( Pt 7): 877–85. PMID 9490632.
- Riley DA, Tan F, Miletich DJ, Skidgel RA (1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
- Ishikawa T, Murakami K, Kido Y; et al. (1998). "Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme". Gene. 215 (2): 361–70. PMID 9714835.
- Reznik SE, Salafia CM, Lage JM, Fricker LD (1999). "Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord". J. Histochem. Cytochem. 46 (12): 1359–68. PMID 9815277.
- Hadkar V, Skidgel RA (2001). "Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium". Mol. Pharmacol. 59 (5): 1324–32. PMID 11306718.
- Fan X, Olson SJ, Blevins LS; et al. (2003). "Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary". J. Histochem. Cytochem. 50 (11): 1509–16. PMID 12417617.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kalinina EV, Fricker LD (2003). "Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking". J. Biol. Chem. 278 (11): 9244–9. PMID 12643288.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- O'Malley PG, Sangster SM, Abdelmagid SA; et al. (2006). "Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells". Biochem. J. 390 (Pt 3): 665–73. doi:10.1042/BJ20050025. PMID 15918796.
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