CRSP3
| Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CRSP3 ; CRSP130; CRSP133; DKFZp434H0117; DRIP130; MED23; SUR2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3552 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa, also known as CRSP3, is a human gene.[1]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]
References
Further reading
- Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
- Rachez C, Lemon BD, Suldan Z; et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
- Näär AM, Beaurang PA, Zhou S; et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
- Boyer TG, Martin ME, Lees E; et al. (1999). "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein". Nature. 399 (6733): 276–9. doi:10.1038/20466. PMID 10353252.
- Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.
- Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. PMID 10823961.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Stevens JL, Cantin GT, Wang G; et al. (2002). "Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit". Science. 296 (5568): 755–8. doi:10.1126/science.1068943. PMID 11934987.
- Asada S, Choi Y, Yamada M; et al. (2002). "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. doi:10.1073/pnas.202162199. PMID 12242338.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Goldberg SF, Miele ME, Hatta N; et al. (2003). "Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP". Cancer Res. 63 (2): 432–40. PMID 12543799.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Sato S, Tomomori-Sato C, Banks CA; et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
- Tomomori-Sato C, Sato S, Parmely TJ; et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Mo X, Kowenz-Leutz E, Xu H, Leutz A (2004). "Ras induces mediator complex exchange on C/EBP beta". Mol. Cell. 13 (2): 241–50. PMID 14759369.
- Sato S, Tomomori-Sato C, Parmely TJ; et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Wada O, Oishi H, Takada I; et al. (2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
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