CSNK2B

Casein kinase 2, beta polypeptide
PDB rendering based on 1jwh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jwh​, 1qf8​, 1rqf​
Identifiers
Symbols	CSNK2B ; CK2B; CK2N; CSK2B; G5A; MGC138222; MGC138224
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55572
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Casein kinase 2, beta polypeptide, also known as CSNK2B, is a human gene.

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.

Further reading

• Schubert U, Schneider T, Henklein P; et al. (1992). "Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II". Eur. J. Biochem. 204 (2): 875–83. PMID 1541298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Teitz T, Eli D, Penner M; et al. (1990). "Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells". Mutat. Res. 236 (1): 85–97. PMID 1694965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Voss H, Wirkner U, Jakobi R; et al. (1991). "Structure of the gene encoding human casein kinase II subunit beta". J. Biol. Chem. 266 (21): 13706–11. PMID 1856204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Litchfield DW, Lozeman FJ, Cicirelli MF; et al. (1991). "Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2". J. Biol. Chem. 266 (30): 20380–9. PMID 1939094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang-Feng TL, Teitz T, Cheung MC; et al. (1991). "Assignment of the human casein kinase II beta-subunit gene to 6p12----p21". Genomics. 8 (4): 741–2. PMID 2276748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ackerman P, Glover CV, Osheroff N (1990). "Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 821–5. PMID 2300566.CS1 maint: Multiple names: authors list (link)
• Heller-Harrison RA, Meisner H, Czech MP (1990). "Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II". Biochemistry. 28 (23): 9053–8. PMID 2513884.CS1 maint: Multiple names: authors list (link)
• Jakobi R, Voss H, Pyerin W (1989). "Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta". Eur. J. Biochem. 183 (1): 227–33. PMID 2666134.CS1 maint: Multiple names: authors list (link)
• Vincent MJ, Abdul Jabbar M (1996). "The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway". Virology. 213 (2): 639–49. PMID 7491787.
• Litchfield DW, Bosc DG, Slominski E (1995). "The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2". Biochim. Biophys. Acta. 1269 (1): 69–78. PMID 7578274.CS1 maint: Multiple names: authors list (link)
• Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. PMID 7689229.
• Gietz RD, Graham KC, Litchfield DW (1995). "Interactions between the subunits of casein kinase II". J. Biol. Chem. 270 (22): 13017–21. PMID 7768894.CS1 maint: Multiple names: authors list (link)
• Szebeni A, Herrera JE, Olson MO (1995). "Interaction of nucleolar protein B23 with peptides related to nuclear localization signals". Biochemistry. 34 (25): 8037–42. PMID 7794916.CS1 maint: Multiple names: authors list (link)
• Arnold SF, Obourn JD, Jaffe H, Notides AC (1995). "Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor". Mol. Endocrinol. 8 (9): 1208–14. PMID 7838153.CS1 maint: Multiple names: authors list (link)
• Pyerin W (1994). "Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation". Adv. Enzyme Regul. 34: 225–46. PMID 7942276.
• el Benna J, Faust LP, Babior BM (1994). "The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases". J. Biol. Chem. 269 (38): 23431–6. PMID 8089108.CS1 maint: Multiple names: authors list (link)
• Schubert U, Henklein P, Boldyreff B; et al. (1994). "The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif". J. Mol. Biol. 236 (1): 16–25. doi:10.1006/jmbi.1994.1114. PMID 8107101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schubert U, Strebel K (1994). "Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments". J. Virol. 68 (4): 2260–71. PMID 8139011.
• Tanasijevic MJ, Myers MG, Thoma RS; et al. (1993). "Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II". J. Biol. Chem. 268 (24): 18157–66. PMID 8349691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Friborg J, Ladha A, Göttlinger H; et al. (1996). "Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8 (1): 10–22. PMID 8548340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)