CTBP1

C-terminal binding protein 1
PDB rendering based on 1hku.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hku​, 1hl3​, 1mx3​, 2hu2​
Identifiers
Symbols	CTBP1 ; BARS; MGC104684
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1015
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

C-terminal binding protein 1, also known as CTBP1, is a human gene.

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

Further reading

• Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. PMID 11864595.
• Schaeper U, Boyd JM, Verma S; et al. (1995). "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (23): 10467–71. PMID 7479821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boyd JM, Subramanian T, Schaeper U; et al. (1993). "A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis". EMBO J. 12 (2): 469–78. PMID 8440238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katsanis N, Fisher EM (1998). "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3". Genomics. 47 (2): 294–9. doi:10.1006/geno.1997.5115. PMID 9479502.
• Schaeper U, Subramanian T, Lim L; et al. (1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. 273 (15): 8549–52. PMID 9535825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sundqvist A, Sollerbrant K, Svensson C (1998). "The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex". FEBS Lett. 429 (2): 183–8. PMID 9650586.CS1 maint: Multiple names: authors list (link)
• Fuks F, Milner J, Kouzarides T (1998). "BRCA2 associates with acetyltransferase activity when bound to P/CAF". Oncogene. 17 (19): 2531–4. doi:10.1038/sj.onc.1202475. PMID 9824164.CS1 maint: Multiple names: authors list (link)
• Sewalt RG, Gunster MJ, van der Vlag J; et al. (1999). "C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins". Mol. Cell. Biol. 19 (1): 777–87. PMID 9858600.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li S, Chen PL, Subramanian T; et al. (1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem. 274 (16): 11334–8. PMID 10196224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. PMID 10359772.
• Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMID 10369679.CS1 maint: Multiple names: authors list (link)
• Holmes M, Turner J, Fox A; et al. (1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. 274 (33): 23491–8. PMID 10438528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furusawa T, Moribe H, Kondoh H, Higashi Y (2000). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1". Mol. Cell. Biol. 19 (12): 8581–90. PMID 10567582.CS1 maint: Multiple names: authors list (link)
• Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811.
• Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". J. Biol. Chem. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
• Melhuish TA, Wotton D (2001). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF". J. Biol. Chem. 275 (50): 39762–6. doi:10.1074/jbc.C000416200. PMID 10995736.
• Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.CS1 maint: Multiple names: authors list (link)
• Izutsu K, Kurokawa M, Imai Y; et al. (2001). "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling". Blood. 97 (9): 2815–22. PMID 11313276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palmer S, Brouillet JP, Kilbey A; et al. (2001). "Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins". J. Biol. Chem. 276 (28): 25834–40. doi:10.1074/jbc.M102343200. PMID 11328817.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schuierer M, Hilger-Eversheim K, Dobner T; et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1". J. Biol. Chem. 276 (30): 27944–9. doi:10.1074/jbc.M100070200. PMID 11373277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)