CYP2C8

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Overview

Cytochrome P₄₅₀2C8 (abbreviated CYP2C8), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

CYP2C8 Ligands

Selected inducers, inhibitors and substrates of CYP2C8

Substrates	Inhibitors	Inducers
cerivastatin (statin) paclitaxel (chemotherapeutic) repaglinide (antidiabetic) torasemide (loop diuretic) ibuprofen (NSAID)	gemfibrozil (hypolipidemic) thiazolidinediones (antidiabetic) rosiglitazone pioglitazone montelukast (leukotriene receptor antagonist) quercetin (antiinflammatory) trimethoprim (antibiotic)	rifampicin (antibiotic)

See also

• Cytochrome P450 oxidase

Further reading

• Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily". Pharmacogenetics. 4 (6): 285–99. doi:10.1097/00008571-199412000-00001. PMID 7704034.
• Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.CS1 maint: Multiple names: authors list (link)
• García-Martín E, Martínez C, Ladero JM, Agúndez JA (2007). "Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals". Molecular diagnosis & therapy. 10 (1): 29–40. PMID 16646575.CS1 maint: Multiple names: authors list (link)
• Ged C, Beaune P (1991). "Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region". Biochim. Biophys. Acta. 1088 (3): 433–5. PMID 1707679.
• Romkes M, Faletto MB, Blaisdell JA; et al. (1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry. 30 (13): 3247–55. doi:10.1021/bi00227a012. PMID 2009263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolyada AY (1990). "Sequence of a human liver cytochrome P-450 cDNA clone". Nucleic Acids Res. 18 (18): 5550. doi:10.1093/nar/18.18.5550. PMID 2216732.
• Shephard EA, Phillips IR, Santisteban I; et al. (1989). "Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family". Ann. Hum. Genet. 53 (Pt 1): 23–31. doi:10.1111/j.1469-1809.1989.tb01119.x. PMID 2729895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ged C, Umbenhauer DR, Bellew TM; et al. (1989). "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase". Biochemistry. 27 (18): 6929–40. doi:10.1021/bi00418a039. PMID 3196692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okino ST, Quattrochi LC, Pendurthi UR; et al. (1987). "Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing". J. Biol. Chem. 262 (33): 16072–9. PMID 3500169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ (1988). "cDNA and amino acid sequences of two members of the human P450IIC gene subfamily". Nucleic Acids Res. 15 (23): 10053–4. doi:10.1093/nar/15.23.10053. PMID 3697070.CS1 maint: Multiple names: authors list (link)
• Zeldin DC, DuBois RN, Falck JR, Capdevila JH (1995). "Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform". Arch. Biochem. Biophys. 322 (1): 76–86. doi:10.1006/abbi.1995.1438. PMID 7574697.CS1 maint: Multiple names: authors list (link)
• Inoue K, Inazawa J, Suzuki Y; et al. (1995). "Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1". Jpn. J. Hum. Genet. 39 (3): 337–43. doi:10.1007/BF01874052. PMID 7841444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gray IC, Nobile C, Muresu R; et al. (1996). "A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24". Genomics. 28 (2): 328–32. doi:10.1006/geno.1995.1149. PMID 8530044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wormhoudt LW, Ploemen JH, de Waziers I; et al. (1996). "Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes". Chem. Biol. Interact. 101 (3): 175–92. doi:10.1016/0009-2797(96)03723-4. PMID 8870687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McFayden MC, Melvin WT, Murray GI (1998). "Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain". Biochem. Pharmacol. 55 (6): 825–30. doi:10.1016/S0006-2952(97)00516-9. PMID 9586955.CS1 maint: Multiple names: authors list (link)
• Macé K, Bowman ED, Vautravers P; et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues". Eur. J. Cancer. 34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID 9797707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klose TS, Blaisdell JA, Goldstein JA (1999). "Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs". J. Biochem. Mol. Toxicol. 13 (6): 289–95. doi:10.1002/(SICI)1099-0461(1999)13:6<289::AID-JBT1>3.0.CO;2-N. PMID 10487415.CS1 maint: Multiple names: authors list (link)
• Finta C, Zaphiropoulos PG (2000). "The human CYP2C locus: a prototype for intergenic and exon repetition splicing events". Genomics. 63 (3): 433–8. doi:10.1006/geno.1999.6063. PMID 10704292.