Coilin

Coilin
Identifiers
Symbols	COIL ; CLN80; p80-coilin
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3413
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Coilin, also known as COIL, is a human gene.

Coilin protein is one of the main molecular components of Cajal bodies (CBs). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. In addition to its structural role, coilin acts as glue to connect the CB to the nucleolus. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.

To study CBs, coilin can be combined with GFP (Green Fluorescent Protein) to form Colin-GFP hybrid protein. The hybrid protein can then be used to locate CBs underneath a microscope, usually near the nucleolus of the cell. Other proteins that make up the CB include snRNPs and nucleolar snoRNPs.

Coilin got its name from the coiled shaped of the CB in which it is found. It was first identified using human autoimmune serum.

Further reading

• Ogg SC, Lamond AI (October 14 2002). "Cajal bodies and coilin — moving towards function". J. Cell Biol. 159 (1): 17–21. doi:10.1083/jcb.200206111. PMID 12379800.
• Andrade LE, Chan EK, Raska I; et al. (1991). "Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin". J. Exp. Med. 173 (6): 1407–19. PMID 2033369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bohmann K, Ferreira JA, Lamond AI (1996). "Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus". J. Cell Biol. 131 (4): 817–31. PMID 7490287.CS1 maint: Multiple names: authors list (link)
• Carmo-Fonseca M, Ferreira J, Lamond AI (1993). "Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure". J. Cell Biol. 120 (4): 841–52. PMID 7679389.CS1 maint: Multiple names: authors list (link)
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kusuda J, Tanuma R, Gotoh E; et al. (1995). "Assignment of a human autoimmune antigen, p80-coilin gene to chromosome 17q21-q23 and of its possible pseudogene to chromosome 14". Hum. Genet. 95 (2): 233–4. PMID 7860074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan EK, Takano S, Andrade LE; et al. (1994). "Structure, expression and chromosomal localization of human p80-coilin gene". Nucleic Acids Res. 22 (21): 4462–9. PMID 7971277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lyon CE, Bohmann K, Sleeman J, Lamond AI (1997). "Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus". Exp. Cell Res. 230 (1): 84–93. doi:10.1006/excr.1996.3380. PMID 9013710.CS1 maint: Multiple names: authors list (link)
• Parfenov VN, Davis DS, Pochukalina GN; et al. (1998). "Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles". J. Cell. Biochem. 69 (1): 72–80. PMID 9513048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pochukalina GN, Davis DS, Kostiuchek DF; et al. (1998). "[Splicing factors in oocyte nuclei from human antral follicles]". Tsitologiia. 40 (4): 239–47. PMID 9644758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. PMID 9679133.CS1 maint: Multiple names: authors list (link)
• Liu J, Hebert MD, Ye Y; et al. (2000). "Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies". J. Cell. Sci. 113 ( Pt 9): 1543–52. PMID 10751146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hebert MD, Matera AG (2001). "Self-association of coilin reveals a common theme in nuclear body localization". Mol. Biol. Cell. 11 (12): 4159–71. PMID 11102515.
• Young PJ, Le TT, Dunckley M; et al. (2001). "Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN". Exp. Cell Res. 265 (2): 252–61. doi:10.1006/excr.2001.5186. PMID 11302690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMID 11641277.CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sleeman JE, Ajuh P, Lamond AI (2002). "snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN". J. Cell. Sci. 114 (Pt 24): 4407–19. PMID 11792806.CS1 maint: Multiple names: authors list (link)
• Hebert MD, Shpargel KB, Ospina JK; et al. (2002). "Coilin methylation regulates nuclear body formation". Dev. Cell. 3 (3): 329–37. PMID 12361597.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shpargel KB, Ospina JK, Tucker KE; et al. (2003). "Control of Cajal body number is mediated by the coilin C-terminus". J. Cell. Sci. 116 (Pt 2): 303–12. PMID 12482916.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sleeman JE, Trinkle-Mulcahy L, Prescott AR; et al. (2004). "Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo". J. Cell. Sci. 116 (Pt 10): 2039–50. doi:10.1242/jcs.00400. PMID 12679382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.