DDEF1

Development and differentiation enhancing factor 1
PDB rendering based on 2da0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2da0​
Identifiers
Symbols	DDEF1 ; PAP; AMAP1; ASAP1; KIAA1249; PAG2; ZG14P
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7684
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Development and differentiation enhancing factor 1, also known as DDEF1, is a human gene.

Further reading

• Brown MT, Andrade J, Radhakrishna H; et al. (1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol. Cell. Biol. 18 (12): 7038–51. PMID 9819391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furman C, Short SM, Subramanian RR; et al. (2002). "DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism". J. Biol. Chem. 277 (10): 7962–9. doi:10.1074/jbc.M109149200. PMID 11773070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott MP, Zappacosta F, Kim EY; et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Loijens JC, Martin KH; et al. (2002). "The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly". Mol. Biol. Cell. 13 (6): 2147–56. doi:10.1091/mbc.E02-01-0018. PMID 12058076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oshiro T, Koyama S, Sugiyama S; et al. (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41): 38618–26. doi:10.1074/jbc.M203453200. PMID 12149250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oda A, Wada I, Miura K; et al. (2003). "CrkL directs ASAP1 to peripheral focal adhesions". J. Biol. Chem. 278 (8): 6456–60. doi:10.1074/jbc.M210817200. PMID 12522101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onodera Y, Hashimoto S, Hashimoto A; et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMID 15719014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ehlers JP, Worley L, Onken MD, Harbour JW (2005). "DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma". Clin. Cancer Res. 11 (10): 3609–13. doi:10.1158/1078-0432.CCR-04-1941. PMID 15897555.CS1 maint: Multiple names: authors list (link)
• Che MM, Boja ES, Yoon HY; et al. (2005). "Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains". Cell. Signal. 17 (10): 1276–88. doi:10.1016/j.cellsig.2005.01.007. PMID 16038802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nusbaum C, Mikkelsen TS, Zody MC; et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto S, Hirose M, Hashimoto A; et al. (2006). "Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 7036–41. doi:10.1073/pnas.0509166103. PMID 16636290.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)