DDX5

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Identifiers
Symbols	DDX5 ; DKFZp686J01190; G17P1; HLR1; HUMP68; p68
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74312
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, also known as DDX5, is a human gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

Further reading

• Iggo RD, Jamieson DJ, MacNeill SA; et al. (1991). "p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts". Mol. Cell. Biol. 11 (3): 1326–33. PMID 1996094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hloch P, Schiedner G, Stahl H (1990). "Complete cDNA sequence of the human p68 protein". Nucleic Acids Res. 18 (10): 3045. PMID 2349099.CS1 maint: Multiple names: authors list (link)
• Ford MJ, Anton IA, Lane DP (1988). "Nuclear protein with sequence homology to translation initiation factor eIF-4A". Nature. 332 (6166): 736–8. doi:10.1038/332736a0. PMID 2451786.CS1 maint: Multiple names: authors list (link)
• Iggo R, Gough A, Xu W; et al. (1989). "Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction". Proc. Natl. Acad. Sci. U.S.A. 86 (16): 6211–4. PMID 2762324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buelt MK, Glidden BJ, Storm DR (1994). "Regulation of p68 RNA helicase by calmodulin and protein kinase C.". J. Biol. Chem. 269 (47): 29367–70. PMID 7525583.CS1 maint: Multiple names: authors list (link)
• Brody LC, Abel KJ, Castilla LH; et al. (1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. PMID 7774924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endoh H, Maruyama K, Masuhiro Y; et al. (1999). "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha". Mol. Cell. Biol. 19 (8): 5363–72. PMID 10409727.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rössler OG, Hloch P, Schütz N; et al. (2000). "Structure and expression of the human p68 RNA helicase gene". Nucleic Acids Res. 28 (4): 932–9. PMID 10648785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV (2000). "The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase". Exp. Cell Res. 257 (2): 272–80. doi:10.1006/excr.2000.4886. PMID 10837141.CS1 maint: Multiple names: authors list (link)
• Watanabe M, Yanagisawa J, Kitagawa H; et al. (2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMID 11250900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akileswaran L, Taraska JW, Sayer JA; et al. (2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi:10.1074/jbc. M101171200 . PMID 11279182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu ZR (2002). "p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex". Mol. Cell. Biol. 22 (15): 5443–50. PMID 12101238.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossow KL, Janknecht R (2003). "Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300". Oncogene. 22 (1): 151–6. doi:10.1038/sj.onc.1206067. PMID 12527917.
• Ogilvie VC, Wilson BJ, Nicol SM; et al. (2003). "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. PMID 12595555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guil S, Gattoni R, Carrascal M; et al. (2003). "Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation". Mol. Cell. Biol. 23 (8): 2927–41. PMID 12665590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita T, Kobayashi Y, Wada O; et al. (2003). "Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells". J. Biol. Chem. 278 (29): 26704–14. doi:10.1074/jbc. M301031200 . PMID 12738788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)