DGKA

Diacylglycerol kinase, alpha 80kDa
PDB rendering based on 1tuz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1tuz​
Identifiers
Symbols	DGKA ; DAGK; DAGK1; DGK-alpha; MGC12821; MGC42356
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1028
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Diacylglycerol kinase, alpha 80kDa, also known as DGKA, is a human gene.

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Further reading

• Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions". J. Biol. Chem. 274 (17): 11447–50. PMID 10206945.
• Schaap D, de Widt J, van der Wal J; et al. (1991). "Purification, cDNA-cloning and expression of human diacylglycerol kinase". FEBS Lett. 275 (1–2): 151–8. PMID 2175712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hart TC, Zhou J, Champagne C; et al. (1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hart TC, Champagne C, Zhou J, Van Dyke TE (1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm. Genome. 5 (2): 123–4. PMID 8180475.CS1 maint: Multiple names: authors list (link)
• Flores I, Casaseca T, Martinez-A C; et al. (1996). "Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation". J. Biol. Chem. 271 (17): 10334–40. PMID 8626603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jones DR, Pettitt TR, Sanjuán MA; et al. (1999). "Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol". J. Biol. Chem. 274 (24): 16846–52. PMID 10358029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanjuán MA, Jones DR, Izquierdo M, Mérida I (2001). "Role of diacylglycerol kinase alpha in the attenuation of receptor signaling". J. Cell Biol. 153 (1): 207–20. PMID 11285286.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanjuán MA, Pradet-Balade B, Jones DR; et al. (2003). "T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation". J. Immunol. 170 (6): 2877–83. PMID 12626538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Hawkins IC, Harvey CD; et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gronert K, Kantarci A, Levy BD; et al. (2004). "A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage". J. Immunol. 172 (3): 1856–61. PMID 14734770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verrier E, Wang L, Wadham C; et al. (2004). "PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase". Circ. Res. 94 (11): 1515–22. doi:10.1161/01.RES.0000130527.92537.06. PMID 15117825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baldanzi G, Mitola S, Cutrupi S; et al. (2004). "Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro". Oncogene. 23 (28): 4828–38. doi:10.1038/sj.onc.1207633. PMID 15122338.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alonso R, Rodríguez MC, Pindado J; et al. (2005). "Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes". J. Biol. Chem. 280 (31): 28439–50. doi:10.1074/jbc.M501112200. PMID 15870081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bacchiocchi R, Baldanzi G, Carbonari D; et al. (2005). "Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase". Blood. 106 (6): 2175–82. doi:10.1182/blood-2005-01-0316. PMID 15928040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yanagisawa K, Yasuda S, Kai M; et al. (2007). "Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation". Biochim. Biophys. Acta. 1771 (4): 462–74. doi:10.1016/j.bbalip.2006.12.008. PMID 17276726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)