DNASE1L3

Deoxyribonuclease I-like 3
Identifiers
Symbols	DNASE1L3 ; DHP2; DNAS1L3; LSD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3630
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Deoxyribonuclease I-like 3, also known as DNASE1L3, is a human gene. This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Tanuma S, Shiokawa D (1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochem. Biophys. Res. Commun. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058.
• Zeng Z, Parmelee D, Hyaw H; et al. (1997). "Cloning and characterization of a novel human DNase". Biochem. Biophys. Res. Commun. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodriguez AM, Rodin D, Nomura H; et al. (1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baron WF, Pan CQ, Spencer SA; et al. (1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. PMID 9714828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. PMID 11141064.
• Wilber A, Lu M, Schneider MC (2003). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection". Mol. Ther. 6 (1): 35–42. PMID 12095301.CS1 maint: Multiple names: authors list (link)
• Boulares AH, Zoltoski AJ, Sherif ZA; et al. (2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells". Cancer Res. 62 (15): 4439–44. PMID 12154052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiokawa D, Shika Y, Tanuma S (2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity". Biochem. J. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMID 12943533.CS1 maint: Multiple names: authors list (link)
• Shiokawa D, Hirai M, Tanuma S (2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. PMID 14646506.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boulares AH, Ren T (2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3". Basic Clin. Pharmacol. Toxicol. 94 (1): 19–29. PMID 14725611.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okamoto M, Okamoto N, Yashiro H; et al. (2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes". Biochem. Biophys. Res. Commun. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boulares H, Zoltoski A, Kandan S; et al. (2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression". Biochem. Biophys. Res. Commun. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)