DNA polymerase beta

Polymerase (DNA directed), beta
PDB rendering based on 1bno.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bno​, 1bnp​, 1bpb​, 1bpd​, 1bpe​, 1bpx​, 1bpy​, 1bpz​, 1dk2​, 1dk3​, 1huo​, 1huz​, 1jn3​, 1mq2​, 1mq3​, 1nom​, 1rpl​, 1tv9​, 1tva​, 1zjm​, 1zjn​, 1zqa​, 1zqb​, 1zqc​, 1zqd​, 1zqe​, 1zqf​, 1zqg​, 1zqh​, 1zqi​, 1zqj​, 1zqk​, 1zql​, 1zqm​, 1zqn​, 1zqo​, 1zqp​, 1zqq​, 1zqr​, 1zqs​, 1zqt​, 1zqu​, 1zqv​, 1zqw​, 1zqx​, 1zqy​, 1zqz​, 2bpc​, 2bpf​, 2bpg​, 2fmp​, 2fmq​, 2fms​, 2i9g​, 2iso​, 2isp​, 2p66​, 7ice​, 7icf​, 7icg​, 7ich​, 7ici​, 7icj​, 7ick​, 7icl​, 7icm​, 7icn​, 7ico​, 7icp​, 7icq​, 7icr​, 7ics​, 7ict​, 7icu​, 7icv​, 8ica​, 8icb​, 8icc​, 8ice​, 8icf​, 8icg​, 8ich​, 8ici​, 8icj​, 8ick​, 8icl​, 8icm​, 8icn​, 8ico​, 8icp​, 8icq​, 8icr​, 8ics​, 8ict​, 8icu​, 8icv​, 8icw​, 8icx​, 8icy​, 8icz​, 9ica​, 9icb​, 9icc​, 9ice​, 9icf​, 9icg​, 9ich​, 9ici​, 9icj​, 9ick​, 9icl​, 9icm​, 9icn​, 9ico​, 9icp​, 9icq​, 9icr​, 9ics​, 9ict​, 9icu​, 9icv​, 9icw​, 9icx​, 9icy​
Identifiers
Symbols	POLB ; MGC125976
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2013
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Polymerase (DNA directed), beta, also known as POLB, is a human gene.

In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]

Further reading

• Date T, Tanihara K, Yamamoto S; et al. (1992). "Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli". Nucleic Acids Res. 20 (18): 4859–64. PMID 1408801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Patel U, Ghosh L, Banerjee S (1992). "DNA polymerase beta mutations in human colorectal cancer". Cancer Res. 52 (17): 4824–7. PMID 1511447.CS1 maint: Multiple names: authors list (link)
• Tokui T, Inagaki M, Nishizawa K; et al. (1991). "Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.". J. Biol. Chem. 266 (17): 10820–4. PMID 2040602.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• SenGupta DN, Zmudzka BZ, Kumar P; et al. (1986). "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning". Biochem. Biophys. Res. Commun. 136 (1): 341–7. PMID 2423078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zmudzka BZ, Fornace A, Collins J, Wilson SH (1988). "Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells". Nucleic Acids Res. 16 (20): 9587–96. PMID 2460824.CS1 maint: Multiple names: authors list (link)
• Widen SG, Kedar P, Wilson SH (1988). "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter". J. Biol. Chem. 263 (32): 16992–8. PMID 3182828.CS1 maint: Multiple names: authors list (link)
• Abbotts J, SenGupta DN, Zmudzka B; et al. (1988). "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme". Biochemistry. 27 (3): 901–9. PMID 3284575.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dobashi Y, Kubota Y, Shuin T; et al. (1995). "Polymorphisms in the human DNA polymerase beta gene". Hum. Genet. 95 (4): 389–90. PMID 7705833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chyan YJ, Ackerman S, Shepherd NS; et al. (1994). "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression". Nucleic Acids Res. 22 (14): 2719–25. PMID 7914364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Chang M, Burmer GC, Sweasy J; et al. (1994). "Evidence against DNA polymerase beta as a candidate gene for Werner syndrome". Hum. Genet. 93 (5): 507–12. PMID 8168825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chyan YJ, Strauss PR, Wood TG, Wilson SH (1996). "Identification of novel mRNA isoforms for human DNA polymerase beta". DNA Cell Biol. 15 (8): 653–9. PMID 8769567.CS1 maint: Multiple names: authors list (link)
• Pelletier H, Sawaya MR, Wolfle W; et al. (1996). "Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity". Biochemistry. 35 (39): 12742–61. doi:10.1021/bi952955d. PMID 8841118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pelletier H, Sawaya MR, Wolfle W; et al. (1996). "A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta". Biochemistry. 35 (39): 12762–77. doi:10.1021/bi9529566. PMID 8841119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pelletier H, Sawaya MR (1996). "Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis". Biochemistry. 35 (39): 12778–87. doi:10.1021/bi960790i. PMID 8841120.
• Kubota Y, Nash RA, Klungland A; et al. (1997). "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein". EMBO J. 15 (23): 6662–70. PMID 8978692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennett RA, Wilson DM, Wong D, Demple B (1997). "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7166–9. PMID 9207062.CS1 maint: Multiple names: authors list (link)
• Sawaya MR, Prasad R, Wilson SH; et al. (1997). "Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism". Biochemistry. 36 (37): 11205–15. doi:10.1021/bi9703812. PMID 9287163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhattacharyya N, Banerjee S (1997). "A variant of DNA polymerase beta acts as a dominant negative mutant". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10324–9. PMID 9294209.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)