DNMT1

DNA (cytosine-5-)-methyltransferase 1
Identifiers
Symbols	DNMT1 ; CXXC9; DNMT; FLJ16293; MCMT; MGC104992
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1055
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

DNA (cytosine-5-)-methyltransferase 1, also known as DNMT1, is a human gene.

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.

See also

• DNA methyltransferase

Further reading

• Yen RW, Vertino PM, Nelkin BD; et al. (1992). "Isolation and characterization of the cDNA encoding human DNA methyltransferase". Nucleic Acids Res. 20 (9): 2287–91. PMID 1594447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bestor T, Laudano A, Mattaliano R, Ingram V (1989). "Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases". J. Mol. Biol. 203 (4): 971–83. PMID 3210246.CS1 maint: Multiple names: authors list (link)
• Hijmans EM, Voorhoeve PM, Beijersbergen RL; et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. PMID 7760804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoder JA, Yen RW, Vertino PM; et al. (1997). "New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase". J. Biol. Chem. 271 (49): 31092–7. PMID 8940105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chuang LS, Ian HI, Koh TW; et al. (1997). "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1". Science. 277 (5334): 1996–2000. PMID 9302295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baylin SB (1997). "Tying it all together: epigenetics, genetics, cell cycle, and cancer". Science. 277 (5334): 1948–9. PMID 9333948.
• Robertson KD, Uzvolgyi E, Liang G; et al. (1999). "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors". Nucleic Acids Res. 27 (11): 2291–8. PMID 10325416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michaelson JS, Bader D, Kuo F; et al. (1999). "Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development". Genes Dev. 13 (15): 1918–23. PMID 10444590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu DW, Lin MJ, Lee TL; et al. (1999). "Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9751–6. PMID 10449766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fuks F, Burgers WA, Brehm A; et al. (2000). "DNA methyltransferase Dnmt1 associates with histone deacetylase activity". Nat. Genet. 24 (1): 88–91. doi:10.1038/71750. PMID 10615135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonfils C, Beaulieu N, Chan E; et al. (2000). "Characterization of the human DNA methyltransferase splice variant Dnmt1b". J. Biol. Chem. 275 (15): 10754–60. PMID 10753866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rountree MR, Bachman KE, Baylin SB (2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat. Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872.CS1 maint: Multiple names: authors list (link)
• Robertson KD, Ait-Si-Ali S, Yokochi T; et al. (2000). "DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters". Nat. Genet. 25 (3): 338–42. doi:10.1038/77124. PMID 10888886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatematsu KI, Yamazaki T, Ishikawa F (2000). "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". Genes Cells. 5 (8): 677–88. PMID 10947852.CS1 maint: Multiple names: authors list (link)
• Mizuno S, Chijiwa T, Okamura T; et al. (2001). "Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia". Blood. 97 (5): 1172–9. PMID 11222358.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fatemi M, Hermann A, Pradhan S, Jeltsch A (2001). "The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA". J. Mol. Biol. 309 (5): 1189–99. doi:10.1006/jmbi.2001.4709. PMID 11399088.CS1 maint: Multiple names: authors list (link)
• Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Di Croce L, Raker VA, Corsaro M; et al. (2002). "Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor". Science. 295 (5557): 1079–82. doi:10.1126/science.1065173. PMID 11834837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pradhan S, Kim GD (2002). "The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity". EMBO J. 21 (4): 779–88. doi:10.1093/emboj/21.4.779. PMID 11847125.
• Rhee I, Bachman KE, Park BH; et al. (2002). "DNMT1 and DNMT3b cooperate to silence genes in human cancer cells". Nature. 416 (6880): 552–6. doi:10.1038/416552a. PMID 11932749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)